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Haem 3154 > VTE > Flashcards

VTE Flashcards

1
Q

what is acute coronary syndrome

A

formation of plaque due to atherosclerosis. when plaque ruptures, blood clot forms causing platelet ana, and blockage of blood flow

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2
Q

virchow’s triad

A

hypercoagulability
vascular damage
circulatory stasis

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3
Q

hypercoag risk factors

A

dehydration
infection
inflammation
thrombophillia

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4
Q

vascular damage risk factors

A

cellulitis
thrombophlebitis
surgery
venous catheters

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5
Q

circulatory stasis risk factors

A

immobility/paralysis
obesity/pregnancy
varicose veins
atrial fibrillation
bradycardia
surgery (anaesthesia>30min)

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6
Q

signs/sx of dvt

A

‘Palpable cord’ due to dilation of veins
Homan’s sign: pain in back of knee on dorsiflexion
Leg swelling, pain, warmth
Oedema
Unilateral

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7
Q

pe s/sx

A

Tachypnoea / tachycardia / diaphoretic
Distended neck veins
Massive PE: hypoxia, hypotensive, cyanotic
Cough, chest pain, chest tightness, SOB, palpitation (need to differentiate from MI)
Hemoptysis (coughing of blood)
Possible dizziness / lightheadedness

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8
Q

reversal for enoxaparin

A

protamine

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9
Q

reversal for warfarin

A

vitamin k, ffp, pcc

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10
Q

indications for thrombolytics

A

3-4.5 hours of onset
high risk PE
hemodynamically unstable

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11
Q

which tpa for vte

A

alteplase, body weight dosing

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12
Q

risk of tpa

A

haemorrhagic conversion

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13
Q

wells score >2 points

A

likely dvt, check if proximal or distal

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14
Q

wells <2 points

A

use d-dimer

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15
Q

negative d-dimer

A

rules out dvt

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16
Q

treat distal/provoked dvt

A

3 months of anti-coag

17
Q

treat proximal/PE

A

consider treatment beyond 3 months, or low dose aspirin upon stopping anticoag

18
Q

which anticoag for poor renal function

A

warfarin/UFH

19
Q

anticoag for pregnant/cancer/liver disease

A

LMWH

20
Q

anticoag for APS

A

warfarin

21
Q

vte treatment apixaban

A

10mg BD (d0-d7), 5mg BD (d8-90)

22
Q

vte treatment rivaroxaban

A

15mg BD (d0-d21), 20mg QD (d22-d90)

23
Q

vte prophylaxis apixaban

A

5mg BD (d90-d180), 2.5mg BD (>d180)

24
Q

vte prophylaxis rivaroxaban

A

20mg (d90-d180), 10mg (>d180)

25
Q

vte treatment dabigatran

A

ufh/lmwh (d0-d5), 150mg BD

26
Q

who should avoid dabigatran

A

crcl<50, pgp inhibitors

27
Q

vte treatment edoxaban

A

60mg qd
(crcl<50: 30mg qd)

28
Q

who should avoid edoxaban

A

crcl>95

29
Q

enox sq dosing

A

1mg/kg/12h

30
Q

warfarin avoid in

A

liver disease

Haem 3154 (4 decks)

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