VSAs Flashcards
Common cause of sepsis in neonates
Group B Streptococcus
Common cause of meningitis in children over 3 months
1) Neisseria Meningitis
2) Streptococcus Pneumoniae
3) Haemophilus Influenzae b
What does Denosumab target?
Receptor activator of nuclear factor kappa-b Ligand (RANK-L) on osteoclasts
Turkish man with a fever and a history of recurrent chest infections. Mutation in the MEFV gene
Familial Mediterranean Fever
ME-FV = MEditerranean FeVer
Person with previous DVT presents with recurrent bruising over the last 5 years and now has pain in their leg
Post-thrombotic syndrome
Which mixed pattern auto-inflammatory condition has over 90% heritability and effects the sacroiliac joint?
Ankylosing spondylitis (HLA-DR27)
Which enzyme would be raised in obstructive or biliary obstruction
Alkaline Phosphatase and Gamma-glutamyl transpeptidase
Hyperthyroidism with low TSH and high thyroxine. Poor uptake on technetium scan
Viral De Quervain’s thyroiditis
Can be used to measure bone turnover and is raised in Paget’s, osteomalacia and rickets
Alkaline Phosphatase
Elderly man has fall and doesn’t lose consciousness but presents 2 days later with confusion
Subdural haemorrhage
Someone hits their head and immediately loses consciousness, then has a lucid interval and presents later with a further loss of consciousness
Extradural haemorrhage
Which clotting factor falls most rapidly after administering warfarin?
Factor VII
Biomarker for medullary thyroid cancer in MEN2
calcitonin
Drug used to treat severe falciparum malaria
Artesunate
quinine second line
Splenomegaly, JAK2 mutation and tear-drop poikilocytes
myelofibrosis
JAK2 mutation = polycythaemia vera or primary myelofibrosis
poikilofcytes = beta-thalassaemia major or myelofibrosis
An African man, with Burkitt’s lymphoma is given Rasburicase. He develops haematuria with irregularly contracted cells. What is the cause?
Glucose-6-phosphate dehydrogenase deficiency
Patient got an aortic valve replacement 3 months ago. Now have jaundice, haemoglobinuria and reticuloctyes.
Mechanical Haemolytic Anaemia
Cancer with the presence of keratin and intercellular bridges
Squamous cell carcinoma
High Na
Low K
Low renin
Conn’s syndrome (primary hyperaldosteronism)
High aldosterone produced by adrenals causes negative feedback on renin production in kidneys –> low renin
Common condition which can be treated with drugs targeting TNF, IL-17 and IL-12/23
Psoriasis
vasculitis involving the external carotid
Giant Cell Arteritis / temporal arteritis
Type of amyloidosis associated with multiple myeloma
Amyloid-light chain amyloidosis
Most common class of drug used to treat HIV
Nucleotide Reverse Transcriptase Inhibitors
Ixodes Tick is the vector for which disease
Lyme disease
Most common lung cancer in non-smokers
Adenocarcinoma
