VRL INFCTNS Flashcards
● severe acute respiratory illness.
● Saudi Arabia in 2012
MIDDLE EAST RESPIRATORY SYNDROME (MERS-CoV)
What is the ETIOLOGIC AGENT OF MERS-CoV?
MERS-Coronavirus
What is the MODE OF TRANSMISSION OF MERS-CoV?
Close contact with infected person
What is the INCUBATION PERIOD OF MERS-CoV?
5 to 6 days, but can range from 2 to 14 days
What are the SIGNS AND SYMPTOMS OF MERS-CoV?
-FEVER
-COUGH
-SHORTNESS OF BREATH
-DIARRHEA
-NAUSEA AND VOMITING
What are the DIAGNOSTIC EXAMS for MERS-CoV?
● Polymerase chain reaction (PCR)
● ELISA
● Polymerase chain reaction (PCR) -
CONFIRMATORY TEST (used to detect viral RNA)
● ELISA-
SCREENING TEST used to detect the presence and concentration of specific antibodies
that bind to a viral protein.
What is the MEDICAL MANAGEMENT for MERS-CoV?
● Currently NO VACCINE is available to treat
MERS-COV
● TREATMENT IS SUPPORTIVE and based on a person’s
clinical condition
What are the PREVENTION for MERS-Cov?
● Wash hands often with soap and water for 20
seconds or use alcohol-based sanitizers
● Cover nose and mouth with tissue when coughing
or sneezing, then throw tissue in the trash.
● Avoid touching the eyes, nose and mouth with
unwashed hands.
● Avoid personal contact such as kissing or sharing
cups or eating utensils with sick people.
● Clean and disinfect frequently touched surfaces
such as doorknobs and toys
is a serious, potentially life-threatening viral infection
SEVERE ACUTE RESPIRATORY SYNDROME (SARS)
caused by the_____________ family, the SARS
associated coronavirus (SARS CoV).
Coronaviridae
● Symptoms related with the lower respiratory tract
● Initially discovered in China
● Characterized by a phase of cytokine storms
SEVERE ACUTE RESPIRATORY SYNDROME (SARS)
What are the SIGNS AND SYMPTOMS OF SARS?
● Fever 38 °C
● Fatigue
● Headaches
● Chills
● Myalgias
● Malaise
● anorexia
Less common features include the following:
- Sputum production
- Sore throat
- Coryza
- Nausea and vomiting -Dizziness
- Diarrhea
Stage 2 is the lower respiratory tract phase and is
characterized by:
● Dry cough
● Dyspnea
● Progressive hypoxemia in many cases
● Respiratory failure that requires mechanical
ventilation
What are the DIAGNOSTIC TESTS for SARS?
● PULSE OXIMETRY
● BLOOD CULTURES
● SPUTUM GRAM STAIN AND CULTURE
- To lure out other infection
●VIRAL RESPIRATORY PATHOGEN TEST- influenza test A and
B viruses and respiratory syncytial virus
- Lure out types of viral infection
● LEGIONELLA AND PNEUMOCOCCAL URINARY ANTIGEN
● WBC-decreased
●Mild hyponatremia and hypokalemia
●Elevated lactate dehydrogenase alanine
aminotransferase and hepatic transaminase
●Elevated creatine kinase level -Serum antibodies to
SARS-CoV in single serum specimen
●RT-PCR (reverse transcriptase polymerase chain
reaction)
●CHEST REDIOGRAPH - interstitial infiltrates
MEDICAL MANAGEMENT for SARS:
● CORTICOSTEROIDS
- Decrease mucus production
● ANTIVIRAL AGENTS (Ribavirin)
● PROTEASE INHIBITORS (Lopinavir, Ritonavir)
● INTERFERON
● MONOCLONAL ANTIBOIDES- emergency prophylaxis,
neutralizes virus activity in vitro and in vivo *
Intravenous immunoglobulin (IVIG)
● NITRIC OXIDE
● GLYCYRRHIZIN - inhibits vitro replication of the virus
● VACCINE- phase 1 clinical trial 2004
What is the ETIOLOGIC AGENT of SWINE FLU (H1N1)?
INFLUENZA A VIRUS SUBTYPE H1N1
What is the MODE OF TRANSMISSION of SWINE FLU (H1N1)?
CLOSE AND DIRECT CONTACT WITH INFECTED PERSON