voyager slides Flashcards
inclusion voyager
symtoms with + imaging
and procedure within the prior 10 days (surgical)
Was plavix allowed in voyager
yes up to 6 mo and median with plavix was 30 days.
50.5 percent
How many pateints voyager
how long
primary event
3k
3 years
major thrombotic events composite, mi, schemic stroke, CV death, ALI and maj amp. (stroke defined dif then compass)
No free lunch quesiton tell me about the bleeding
when we unblinded we were suprsied by the low bleeding risk
-Major bleeding 0.96 vs. 0.67 (not sign) crossed 0.
when we added clopidogrel was there a difference
Usually dont give clopidogrel no benefit seen (non randomized use). Dont see improved efficacy and some incresase in bleeding. ie DCB
However that may be schewed bc not randomized.
Euclid
PEgasus
Why so few patients in the US
WP CLI
why trial 5 g hb drop
WP of cliostazole in trial
Clodipogrel vs. Ticagrelor - no ASA, no evidence that ticag helped.
- patients with MI 60 mg decreased MACE but not mortality and increassed bleeding.
Having trouble enrolling in the us.
30%
TIMI ggt
ISTH - higher numbers (gets toward higher beedling rate)
10% (has some antiplt effect)
how do you reconcile the lack of benefit in Voyager seen in Compass?
Only 30% of PAD patients with CAD so coronary event rates were expectly low…
“I know you know this I just have to go through ti”
dont give if bleeding.
Voyager vs. Compass PAD
Voyager no difference in timi major bleeding.
Bleeidng were higher in compass pad but rare < 3%
