Voltage gated K+

Question 1

How does calcium channels influence gating?

Answer 1

INCREASE CALCIUM, INCREASE OPENING FORCE, K+ efflux.

Question 2

what is maxi k

Answer 2

voltage dependant and therefore Ca2+ dependant

Question 3

In maxi K channels, as the concentration of Ca2+ increases…

Answer 3

the channel requires less electrical activity to open

Question 4

what is TREK 1

Answer 4

A K2p family channel that has P loop and only needs TWO subunits TO MAKE A PORE

Question 5

what happens when TREK 1 is at rest

Answer 5

its open

Question 6

How are complex shapes and firing patterns of the A.P made IN NEURONES?

Answer 6

1)Voltage-gated Ca2+ channels allows Ca to enter giving a ‘BURST’ in MP

2)High [Ca] inside activates Ca2+-activated K+ channels

3) [Ca] inside decreases, K channel closes, neurone depolarises

4) another spike as calcium channels open again.

Question 7

how many genes code for these channels

Answer 7

70 genes
6 segments; one pore 2 segments one pore 4 segments 2 pore (TREK)