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Biomembranes > GABA > Flashcards

GABA Flashcards

1
Q

GABAaR is what kind of channel

A

transmitter gated anion channel

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2
Q

GABAbR is what kind of receptor

A

G protein coupled receptor

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3
Q

Drugs that enhance the GABAaR are called what

A

positive allosteric modulators

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4
Q

what are positive allosteric modulators

A

drugs that enhance GABAaR function

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5
Q

What kind of dimer is GABAbR

A

heterodimer

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6
Q

What are the 2 alphas on the GABAbR

A

alphai
alphaO

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7
Q

name a selective GABAbR agonist

A

baclofen

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8
Q

what is baclofen

A

GABAbR agonist

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9
Q

why is baclofen administered to patients

A

treat certain types of spasticity

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10
Q

how is alpha - ketoglutarate converted to glutamate

A

GABA T

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11
Q

how is glutamate converted to GABA

A

Glutamic acid decarboxylase

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12
Q

activation of glutamate gated cation conducting channels produce what?

A

excitatory postsynaptic potential (EPSP)

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13
Q

activation of GABA-gated anion conducting channels produce what

A

inhibitory post synaptic potential (IPSP)

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14
Q

the firing of the pyramidal neuron causes what

A

activates an inhibitory interneuron

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15
Q

once the inhibitory interneuron is activated what does it inhibit

A

the pyramidal neuron

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16
Q

when can the pyramidal neuron start to fire again

A

once the inhibition has decayed

17
Q

What does the Gi alpha subunit inhibit

A

adenylate cyclase

18
Q

once the Gi alpha subunit has inhibited adenylate cyclase what does this decrease

A

cAMP levels

19
Q

postsynaptic GABAb activation causes the Gi betagamma complex to open what
what will this cause

A

a K+ channel
hyperpolarisation

20
Q

presynaptic GABAb activation causes the Go betagamma to decrease what
and what does this decrease

A

voltage gated Ca2+ channels opening
decreasing quantal release of neurotransmitter

21
Q

GABA acts post-synaptically to activate what
what does this produce

A

chloride conducting GABAaRs
produces IPSP

22
Q

GABA acts pre synaptically to activate what
what does this reduce the probability of

A

GABAbRs
reduces the probability of Ca2+ channel opening and consequently decrease GABA release upon a second stimulus

23
Q

Drugs that inhibit GABAaR function are

A

pro convulsant
anciogenic

24
Q

benziodiazepines ______ the probability of the channel opening

A

increases

25
Q

barbituates ____ channel open states of long duration

A

promote

26
Q

barbituates at higher concentrations directly ______ the receptor

A

activate

27
Q

which alpha subunits does diazepam enhance and which does it not

A

alpha 1,2,3,5
not -> alpha 4

28
Q

what is an agonist of GABAb

A

baclofen

29
Q

what is an antagonist of GABAb

A

saclofen

Biomembranes (4 decks)

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