VL21: Mouse models

Question 1

Why do we use animal models?

Answer 1

• study course of infection (kochs 3, postulate
• testing of antimicrobial compounds
• why animal models? more ethical than infecting human volunteers
• often no good animal modes

Question 2

2 messages

Answer 2

people take these studies seriously (needs valid reason)

it is not A model, several models in different bodyparts

Question 3

What are some differences between mice and humans? 2 disease examples

Answer 3

kjn

Question 4

Name some other animals that are used as models?

Answer 4

kjn

Question 5

Give some examples of what kind of tests you could do?

Answer 5

kjh

Question 6

What has to be considered when using animal models?

Answer 6

kjh

Question 7

what are the limitations of animal models?

Answer 7

kj

Question 8

how are the models validated

Answer 8

jknh

Question 9

What has to be considered when designing the experiment?

Answer 9

kh

Question 10

What are the ways in whichthe substances can be administered?

Answer 10

kjh

Question 11

What is the problem with anesthesis? analgetic

Answer 11

khj

Question 12

What factors influence antimicrobial activity in in vivo tests?

Answer 12

bnj

Question 13

Why use mice in particular?

Answer 13

kjhn

Question 14

What are LD50 and ID50 and what are their ethical considerations

Answer 14

lkjh

Question 15

What is a competition assay?

Answer 15

kjh

Question 16

How and for what is a murine thigh infection model used?

Answer 16

kjh

Question 17

How is a murine UTI model used?

Answer 17

kljh

Question 18

How is a murine pneumonia model used?

Answer 18

kjh

Question 19

How is a murine skin infection model used?

Answer 19

kjh

Question 20

How is a murine peritonitis model used?

Answer 20

kjh