Vitamins Flashcards
Vitamin A: Functions
Vision (rhodopsin), immunity, growth
Vitamin A: Sources
Preformed: Animal Products; PrOformed: red/orange/yellow plants & dark green leafy veggies
Vitamin A: Deficiency
eye problems: night blindness, xerosis, xeropthalmia, Bitot’s Spots
What is the #1 nutritional deficiency world wide?
Vitamin A
Vitamin A: Toxicity
dry skin, bone pain, hair loss
Vitamin D (calciferol): Functions
prohormone, calcium & phosphorus absorption
Vitamin D (calciferol): Sources
D3 (cholecalciferol): fortified dairy, fatty fish, hydroxylated in liver and kidneys to fully activate as calcitriol
Vitamin D becomes fully activated in which organs and into what compound?
Vitamin D is hydroxylated to Calcitriol in the liver and kidneys
Vitamin D (calciferol): Deficiency
Rickets, Autoimmune disease
Vitamin D (calciferol): Toxicity
Hypercalcemia
Vitamin D (calciferol): RDA
<1 = 400 IU/D; 1-70 = 600 IU/D; >70 = 800 IU/D
Vitamin E (Tocopherol): Functions
Antioxidant in plasma membrane
Vitamin E (Tocopherol): Sources
Nuts/Seeds, Vegetable Oil, Olive Oil, Peanut Butter
Vitamin E (Tocopherol): Deficiency
hemolytic anemia in infants, peripheral neuropathy
Vitamin E (Tocopherol): Toxicity
No known toxicity from foods; supplements may thin the blood
Vitamin K (Phylloquinone & Menoquinone): Functions
Formation of carboxyglutamates in clotting (fibrinogen pathway) and bone formation (osteocalcin); Side note: carboxyglutamates are calcium-binding sites
Vitamin K (Phylloquinone): Sources
Dark green leafy veggies
Vitamin K (Menoquinone): Sources
meat, eggs, also produced by gut bacteria
Vitamin K (Phylloquinone & Menoquinone): Deficiency
increased blood loss due to lack of clotting, (shots of vitamin K are given to infants at birth to prevent vitamin K-associated bleeding in the brain
Vitamin K (Phylloquinone & Menoquinone): Toxicity
None
Vitamin C (Ascorbic Acid): Functions
antioxidant (regenerates vitamin E), required for collagen synthesis (formation of hydroxyproline & hydroxylysine), nonheme iron absorption
Vitamin C (Ascorbic Acid): Sources
citrus fruits, peppers
Vitamin C (Ascorbic Acid): Deficiency
Scurvy
Vitamin C (Ascorbic Acid): Toxicity
Diarrhea
Vitamin C (Ascorbic Acid): RDA is higher in which population?
smokers have higher requirements than non-smokers
Thiamin (B1): Functions
coenzyme (TPP/TDP - Thiamin pyrophosphate), noncoenzyme (TTP - Thiamin triphosphate), Required by nervous system
Thiamin (B1): Sources
Enriched Grains, meats, legumes; (raw fish contain thiamin degrading enzymes)
Thiamin (B1): Deficiency
Fatigue, weakness, Beriberi, Wernicke’s Encephalopathy in Alcoholics
Acute beriberi - infants
Wet beriberi - adults
Dry beriberi - older patients (muscle weakness, calf pain, difficulty walking
Thiamin (B1): Toxicity
None
Riboflavin (B2): Functions
Coenzyme (FAD & FMN) in Krebs and ETC, niacin synthesis (used by dehydrogenases)
Riboflavin (B2): Sources
Milk, enriched grains, organ meats
Riboflavin (B2): Deficiency
Ariboflavinosis: Magenta tongue, glossitis, cheilosis, angular stomatitis
Riboflavin (B2): Toxicity
None
Niacin (B3): Function
Coenzyme (NAD-used by dehydrogenases & NADPH-building pathways, lipid & cholesterol synthesis and fatty acid elongation)
Niacin (B3): Sources
Meat, fish, enriched grains
Niacin (B3): Deficiency
Pellagra: (4 D’s): dermatitis, diarrhea, dementia, death
Niacin (B3): Toxicity
supplements can cause flushing (hot flashes)
Pantothenic Acid (B5): Functions
part of Coenzyme A (CoA) & acyl carrier protein (ACP)
- metabolism of carbs, lipids & proteins
- synthesis of fatty acids, cholesterol, steroid hormones, hemoglobin, acetylcholine, melatonin
Pantothenic Acid (B5): Sources
Widespread
Pantothenic Acid (B5): Deficiency
RARE; burning feet syndrome
Pantothenic Acid (B5): Toxicity
None
Biotin (B7): Functions
Coenzyme for carboxylases (FA synthesis, gluconeogenesis)
Biotin (B7): Sources
liver, cooked eggs, soy, non-wheat cereals, meat, tomatoes
Biotin (B7): Deficiency
birth defects, alopecia, fatigue
Biotin (B7): Toxicity
None
Choline: Functions
cellular integrity as part of phosphatidyl choline (lecithin), part of lipoproteins & acetylcholine
Choline: Sources
Soy, milk, eggs, peanuts
Choline: Deficiency
liver & muscle damage, neural tube defects
Choline: Toxicity
decreased growth, fishy body odor, excessive sweating & salivation
Pyridoxine (B6): Functions
coenzyme (pyridoxal phosphate, PLP) for amino acid metabolism, synthesis of: niacin, collagen, carnitine, heme, sphingomyelin
Pyridoxine (B6): Sources
Meats, enriched grains
Pyridoxine (B6): Deficiency
peripheral neuropathy, microcytic hypochromic anemia (because its required for heme synthesis)
Pyridoxine (B6): Toxicity
peripheral neuropathy
Folate (B9): Functions
methylation reactions (1 carbon metabolism) in DNA synthesis and cell replication
Folate (B9): Sources
Dark leafy veggies (spinach, kale), legumes (beans); folic acid is the synthetic form in both supplements and fortified foods
Folate (B9): Deficiency
neural tube defects, megaloblastic macrocytic anemia
Folate (B9): Toxicity
Folic Acid supplements can mask a B12 deficiency causing permanent nerve damage
Cobalamin (B12): Functions
Coenzyme: methylcobalamin-formation of S-adenosylmethionine required for MYELINATION; Adenosylcobalamin = Amino acid metabolism
Cobalamin (B12): Sources
meats (B12 requires IF secreted by gastric parietal cells to be absorbed)
Cobalamin (B12): Deficiency
megaloblastic macrocytic anemia, peripheral neuropathy
Cobalamin (B12): Toxicity
None