Minerals Flashcards
What are the general functions of minerals?
Bone Cell Signaling Fluid Balance/Osmotic Pressure Metabolic Processing of Macronutrients Oxygen Transport
Describe general mineral metabolism:
Dissolution in liquid frees ionic mineral from the salt form it is consumed in
What influences general mineral absorption:
influenced by food as well as the body’s need
What increases mineral absorption?
acidic environment
some proteins or sugars
What decreases mineral absorption?
consuming with binders such as oxalate, phytate & tannins
What foods contain Oxalate binders?
Beans, greens, nuts, berries
What foods contain the Phytate binders?
Whole grains, legumes, seeds
What foods contain Tannins binders?
Tea, coffee, wine, red berries, red beans
How are minerals transported in the body?
They are bound to plasma or specific transport proteins
What regulates tissue uptake of minerals?
Hormones regulate it
How are minerals found in the body?
Free ions in body fluids: Electrolytes
Bound to other minerals as salts: Hydroxyapatite
Bound to organic compounds like proteins: Hemoglobin
Which minerals are considered major minerals?
Calcium Phosphorus Potassium Sodium Magnesium Chloride
Which minerals are considered trace minerals?
Iron Copper Zinc Iodine Selenium Manganese Molybdenum Fluoride
What are the Functions of Calcium?
Bone
Cell Signaling: stored in sarcoplasmic reticulum, released for clotting and muscle contraction
What is the RDA for Calcium?
4-8yrs: 1000mg/d
9-18 yrs: 1300mg/d
19-50yrs: 1000mg/d
>50yrs: 1200mg/d
What are some of the best sources of Calcium,?
Dairy, non dairy milk, low-oxalate greens: kale, broccoli
What is a deficiency of Calcium called and how does it present?
Hypocalcemia; tetany, osteoporosis
What is a toxicity of Calcium called and how does it present?
Hypercalcemia; calcification of soft tissues, hallucinogens, constipation
watch for parathyroid tumors in older patients
What mineral absorption may be impacted by hypercalcemia and how?
Decreased absorption of iron, magnesium, phosphorus and zinc
What are the functions of Phosphorus?
Bone Phosphate in ATP cAMP Phospholipids DNA & RNA Buffer
What are some good sources of Phosphorus?
animal producs, dairy, eggs
What is a deficiency of Phosphorus called and how does it present?
Hypophosphatemia; bone loss in those consuming large amounts of aluminum-containing antacids
What is a toxicity of Phosphorus called and how does it present?
Hyperphosphatemia; bone resportion when Ca:P ratio is <1 for a significant amount of time leads to nutritional secondary hyperparathyroidism
What are the functions of Magnesium?
Bone
Muscle relaxation (calcium channel blocker)
Cofactor for 300 enzymes using ATP (stabilizes ATP)
What are some good sources of Magnesium?
Nuts, seeds, legumes, seafood
What is a deficiency of Magnesium called and how does it present?
Hypomagnesemia; muscle weakness, cramps, headaches
What is a toxicity of Magnesium called and how does it present?
No toxicity from foods; supplements & meds cause slurred speech and diarrhea
What are the functions of sodium?
Water balance(MAJOR CATION IN ECF), muscle action(Na+/K+ pumps), nutrient absorption
What are the main sources of sodium?
Table salt, cured meats, canned soup
What is a deficiency of sodium called and how does it present?
Hyponatremia; muscle cramps, seizures (can be caused by head trauma)
What is a toxicity of sodium called and how does it present?
Hypernatremia; hypertension, edema, excessive calcium excretion causing hypocalcemia
What are the functions of Potassium?
Water balance (MAJOR CATION IN ICF), muscle action (Na+/K+ pumps), insulin release from beta cells, blood pressure
What are some good sources of potassium?
Sweet potatoes, banana, avocado, dairy
What is a deficiency of potassium called and how does it present?
Hypokalemia; arrhythmia, muscle weakness
What is a toxicity of potassium called and how does it present?
Hyperkalemia: arrhythmia
What are the functions of Chloride?
water balance (MAJOR ANION IN ECF), HCl in digestion, chloride shift in RBC during respiration
What are good sources of Chloride?
table salt, cured meats, canned soup
What is a deficiency of chloride called/result in?
Metabolic Alkalosis
What is a chloride toxicity called/result in?
None, it doesn’t exist
What are the functions of Iron?
Oxygen transport, cofactor for enzymes (catalase), part of cytochromes
What is a good source of heme iron?
Red meat
What are good sources of non-heme iron and what else is required?
Plants & Supplements (also require Vitamin C)
What is the Iron RDA for males & postmenopausal females?
8mg/day
What is the Iron RDA for females of childbearing age?
18 mg/day
What is the #1 nutritional deficiency in the US?
Iron deficiency
What is characteristic of Iron deficiency?
may be with or without microcytic hypochromic anemia, fatigue, pallor
What is characteristic of Iron toxicity?
fatal in large quantities, nausea/vomiting
What is a genetic condition involving excess Iron?
Hemochromatosis
Which Iron binding proteins are found in the SI, Liver, Spleen and bone marrow?
Ferritin
What is the function of Ferritin?
Iron Stores
Which Iron binding protein is only found in the SI?
Ferroportin
What is the function of Ferroportin?
Transports Iron across the basolateral membrane
requires Cu
Which Iron binding protein is responsible for transporting iron in the plasma?
Transferrin
What are the functions of Zinc?
Cofactor for growth processes, protein metabolism, immune system, taste, CYTOSOLIC superoxide dismutase (SOD1 & SOD3)
What are the sources of Zinc?
OYSTERS, meat, legumes(contain phytate)
What is characteristic of a Zinc deficiency?
stunted growth, impaired taste, poor wound healing, decreased immune function
Acrodermatitis Enteropathica
What can occur with Zinc toxicity?
decreased copper absorption
What are the functions of Copper?
part of CERULOPLASMIN(transport iron out of the enterocyte), cofactor for SOD1 & SOD3, part of cytochrome c oxidase
What are good sources of Copper?
OYSTERS, Cocoa
What is associated with a Copper deficiency?
Menkes’ Disease
What is associated with a Copper toxicity?
Wilson’s disease, Kayser-Fleisher rings, liver damage
What functions is Iodine involved with?
Thyroid hormones (T3 & T4)
What are good sources of Iodine?
Seafood, Iodized Salt
True or False: Salt in processed food is commonly iodized?
False
What are the symptoms of an Iodine deficiency?
goiter, cretinism, mental impairment, hypo-/ hyperthyroidism
What is the #1 cause of preventable brain damage in the world?
Iodine deficiency
What are the symptoms of an Iodine toxicity?
iodine-excess goiter, autoimmune thyroiditis, hypothyroidism, elevated TSH
What are the functions of Selenium?
Cofactor for glutathione peroxidase, conversion of T4 to T3, part of selenoproteins
What are some good sources of Selenium?
BRAZIL NUTS, anything from the ground
What is generally associated with a Selenium deficiency?
oxidative stress in the thyroid
What is it called when a Selenium deficiency produces cardiomyopathy?
Keshan Disease
What is it called when a Selenium deficiency produces joint deficiency?
Kashin-Bek disease
What is commonly associated with Selenium toxicity?
hair loss and joint pain
What are the functions of manganese?
Cofactor for bone and carb metabolism may be used instead of magnesium by some enzymes
What general group of foods is a good source of manganese?
Plants
What is associated with a manganese deficiency?
Impaired growth
What usually causes a manganese toxicity?
Inhalation by miners
What symptoms may be seen with a manganese toxicity?
Seizures & Memory loss
What are the functions of Chromium?
Insulin release & action (part of glucose tolerance factor)
What are common sources of Chromium?
Brewer’s Yeast, grains
What symptom may indicate a chromium deficiency?
Impaired blood sugar regulation
Toxicity due to supplements of Chromium may damage what structures/organs?
Nerves, Kidneys and Liver
What are the functions of Molybdenum?
Cofactor for many enzymes: Xanthine Oxidase; Involved with purine metabolism during repurfusion injury
What are sources of molybdenum?
Organ Meats, dairy, grains
True or False: It is unlikely to have a molybdenum deficiency?
True
What is associated with molybdenum toxicity and how does it occur?
Gout, from supplements
What tissues/structures is Fluoride important for?
Bones/Teeth
What are common sources of Fluoride?
Fluoridated water, toothpaste, tea (natural)
What is associated with fluoride deficiency?
Dental carries (Cavities)
What is associated with Fluoride toxicity?
Fluorosis, bone pitting