Vitamin Supplementation Flashcards
Water soluble vitamins
B1, B2, B3, B6, B12, folate/B9, C
Fat soluble vitamins
A, D, E, K
Energy-releasing vitamins
B1 (thiamine), B2 (riboflavin), B3 (niacin)
Hematopoiesis vitamins
B6 (pyridoxine), B12 (cyanocobalamin), B9 (folate)
Physiologic role of B1/thiamine
Coenzyme in the intermediary metabolism of multiple essential reactions
Physiologic role of B2/riboflavin
Plays a role in numerous respiratory systems
Physiologic role of B3/niacin
Component of two coenzymes
Physiologic role of B6/pyridoxine
Coenzyme in amino acid metabolism
Physiologic role of B12/cyanocobalamin
B12 coenzymes are essential for cell growth and replication
Physiologic role of B9/folic acid
DNA synthesis and hematopoiesis
Physiologic role of Vitamin C/ascorbic acid
Cofactor for electron transfer to enzymes, required for collagen synthesis and wound healing
Physiologic role of vitamin A
Essential in retinal function, growth and differentiation of epithelial tissue, enhances immune function, bone growth, reproduction, embryonic development
Physiologic role of vitamin E
Antioxidant
Physiologic role of vitamin D
Synthesized from cholesterol upon exposure to UVB; functions in the body as a steroid hormone
Recommended dietary allowance (RDA) definition
Average daily level of intake sufficient to meet the nutrient requirements of nearly all healthy individuals
Adequate intake (AI) definition
Established when evidence is insufficient to develop on RDA; intake of this level is assumed to ensure nutritional adequacy
Estimated average requirement (EAR) definition
Average daily level of intake estimated to meet the requirements of 50% of healthy individuals
Tolerable upper intake level (UL) definition
Maximum daily intake unlikely to cause adverse health effects
B1 deficiency is likely to happen in what population?
Alcoholics
Complications of B1 deficiency
Wernicke’s Encephalopathy, Korsakoff’s Psychosis
Symptoms of Wernicke’s Encephalopathy
Confusion, nystagmus, ataxia
Treatment for Wernicke’s Encephalopathy
50-100mg IV thiamine
How does Korsakoff’s Psychosis develop and what are the symptoms?
If Wernicke’s Encephalopathy is untreated, it can develop to Korsakoff’s Psychosis, a chronic state of irreversible damage and cognitive impairment
Symptoms of B2 deficiency
Glossitis, cheilosis, dermatitis, corneal vascularization, cataracts, anemia
Symptoms of B3 deficiency
Pellagra: diarrhea, dementia, dermatitis
B6 INH treatment
15-30mg/day for patients predisposed to neurotoxicity, 50-200mg/day in established neuropathy
DDIs with B6: levodopa
Enhances peripheral decarboxylation
DDIs with B6: phenobarbital, phenytoin
Decreased SDCs