Vitamin E Studies

Question 1

IOM RDA

Answer 1

15mg (EAR 12mg)

Question 2

EFSA (AI)

Answer 2

13, 11 mg

Question 3

The dietary requirement for vitamin E has been based on many outcomes

Answer 3

1)Intakes providing plasma α-toc concentrations that inhibit hydrogen peroxide-induced hemolysis.2)Intakes related to the amount and degree of unsaturation of dietary PUFAs3)Intake dose relationship with plasma α-toc concentration, urinary α-CEHC excretion, adipose tissue α-toc concentration, markers of oxidative damage and other biomarkers of function

Question 4

CVD

Answer 4

24% reduced risk for >30uM

J-shaped curve

Question 5

HOPE-TOO

Answer 5

Participants taking vitamin E were 13% more likely to experience, and 21% more likely to be hospitalized for, heart failure, a statistically significant but unexpected finding not reported in other large studies.

Question 6

Cancer

Answer 6

Select Trial: 17% increased risk of prostate cancer compared to placebo

Question 7

Ref Serum

Answer 7

12 –46 μmol/L

Question 8

Median Intake

Answer 8

8.2mg (with supplements)