Structures

Question 1

Vitamin E (alpha-toc)

Answer 1

Trimethylated chromanol ring with saturated tail

Question 2

alpha, beta, gamma, delta Vit E differ by…

Answer 2

…methylation levels and position

Question 3

Alpha-toc stereogenic centres

Answer 3

Position 2 on the ring, 4 and 8 on the chain

Question 4

Vit E activity

Answer 4

RRR, RSR, RRS, RSS

Question 5

Active site for scavenging free radicals

Answer 5

position 6

Question 6

Vitamin K structure

Answer 6

3 subsituted 2 methyl 1, 4 napthoquinone

Question 7

K1 structure

Answer 7

With a phytyl side chain

Question 8

K2 structure

Answer 8

4 to 13 isoprenyl units (unsaturated)

Question 9

K3

Answer 9

Menadione, parent compound - water soluble?

Question 10

Vit K main function

Answer 10

Carboxylation - post-translational modification (synthesis) of Gla to Glu (the active form is reduced)

Question 11

Factors in blood coagulation and proteins

Answer 11

II, VII, IX, X and proteins C, S, Z

Question 12

Vitamin K active form

Answer 12

Reduced form is active - when oxidised, it is converted to an epoxide