Vitamin E

Question 1

alpha tocopherol

Answer 1

one form of vitamin E

Question 2

Tocopherol

Answer 2

no double bond on nonpolar chain

Question 3

Tocotrienol

Answer 3

double bond on chain

Question 4

Different vitamin E

Answer 4

alpha - 3 methyl groups
gamma - 2 methyl groups
delta - 1 methyl group

Question 5

Natural v. Synthetic

Answer 5

Mixture of 8 steroisomers (syn)

RRR d-alpha-tocopherol

Question 6

Function of Vitamin E

Answer 6

antioxidants

• deactivates liphlic free radicals
• retards peroxidation UFA

Question 7

Vitamin E on free radical

Answer 7

ROO* —> ROOH

This occurs from an H transfered from HO-vitamin E to the free radical. O-vitamin E is very stable.

Question 8

GPx-4

Answer 8

-O-OH –> -OH

Question 9

Vitamin C effects on Vitamin E

Answer 9

Vitamin C donates an electron (H) to Vitamin E. While, NADPH donates an electron to vitamin C.

Question 10

Vitamin E status

Answer 10

• dietary vitamin e intake
• serum lipoprotein concentration
• CYP450
• TTP

Question 11

CYP4F2

Answer 11

meabolize vitamin E

expressed in the liver

Question 12

TTP

Answer 12

it is present in the brain
it binds and transfers RRR-alpha-tocopherol from one membrane to another
it moves the vitamin E to a lipoprotein