Visual Development and Neural Plasticity Flashcards

1
Q

synaptic plasticity

A
  • ability of a synapse between two neurons to change in strength or effectiveness
  • visual/sensory experience vs. genetic/intrinsic programming vs. intrinsic development cues and rules
  • is the adult brain plastic?
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2
Q

binocular interaction

A

-first site is primary visual cortex

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3
Q

proline injection

A
  • revealed the pattern of ocular dominance in cortex in adult
  • not one in babies
  • at various time points shows none at 2 weeks and present by 13 weeks
  • when LGN afferents first invade cortex, they come in unsegregated according to eye of origin
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4
Q

congenital cataract

A
  • removed too late- after 10- functionally blind
  • adult was ok
  • amblyopia
  • something special between early childhood and adulthood
  • psychologists had known about learning other behaviors- language
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5
Q

OD scale

A
  • 1 is contra
  • 4 is binocular
  • 7 is ipsi
  • if you deprive one side it won’t develop correctly
  • the good eye takes over territory normally occupied by the other eye
  • remodeling happens in cats too
  • occlusion for as little as 6-7 days has an effect
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6
Q

monocular deprivation at different times

A
  • led to discovery of a critical period

- 1 year better than 2 or 10 weeks, 6 years had little effect

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7
Q

binocular deprivation

A
  • extends critical period
  • leads to few binocular sides
  • issue isn’t disuse it’s competition
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8
Q

critical period

A
  • language and speech
  • sensory-motor and social
  • as well as eyes
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9
Q

strabismus

A
  • peripheral disorder
  • involves extraocular muscles
  • causing misalignment of the two eyes, preventing proper binocular vision
  • leads to amblyopia in younger children
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10
Q

amblyopia

A
  • lazy eye
  • central disorder resulting from an imbalance or lack of visual coordination between the two eyes during development
  • leads to poor vision or acuity in one eye compared to strong eye
  • can also be caused by refractive errors and cataracts
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11
Q

two distinct issues

A
  • must correct source of binocular balance to address amblyopia
  • normal requires match of strength of input from each eye and a coordination of inputs- seeing the same thing at the same time
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12
Q

binocular vision

A
  • proper convergence of two eyes and matching refraction and image quality
  • allows nascent binocular cortical cells to receive conjoint, synchronous activity arising form the viewing of the same object in each eye
  • why- synaptic pruning
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13
Q

steriopsis

A
  • depth vision

- poor for both binocular deprivation and strabismus

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14
Q

alternation

A
  • other result of strabismus- each eye on in alternating fashion so strength is near same
  • no binocular vision
  • amblyopia gives same diagram as oppression- lose that one eye
  • need to pick one way in order to avoid diplopia
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15
Q

Hebb’s hypothesis

A
  • any two cells that are repeatedly active at the same time will become associated- one activity facilitates activity in the other
  • axon strengthening
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16
Q

axon strength and eyes

A
  • if axons aren’t stimulated, they die
  • might need multiple synapses to prevent this
  • in monocular deprivation, deprived eye has weaker and fewer synapses
17
Q

TTX injections

A
  • stimulate with electrode
  • asynchronous pulsing divides axons in V1
  • synchronous pulsing causes them to grow together in V1
18
Q

NMDA

A
  1. antagonists reduce ocular dominance plasticity and the refinement of receptive field properties
  2. overall concentration of NMDA receptors in the visual cortex peaks with critical period
  3. NMDA contribution to the visual response drops in layers 4, 5, and 6 as ocular dominance columns segregate
  4. Rearing in dark postpones these changes, as it does ocular dominance segregation and other events during the critical period
    - critical component
19
Q

3 eyed frog

A

-activity based competition leads to segregation even in a system that normally lacks it

20
Q

plasticity

A

-time window is correlated with the cellular age of inhibitory neurons

21
Q

adult plasticity

A

blind spot

  • fill in
  • if we take away some of the cortex, we will replace with outside the normal region of input
  • grows new connections, expands territory
  • take away fingers- re learn
  • phantom limbs
  • stevie wonder?