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Microbiology > Viruses specials > Flashcards

Viruses specials Flashcards

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Biology 101 flashcards
1
Q

EBV

A

EBV gp350 binds to CD 21 (CR 2)

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2
Q

Adenovirus

A

Hexone and Pentone capsomeres- rodlike projections from Pentone based capsomeres interact with transmembrane protein members from Ig superfamily

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3
Q

Parvovirus

A

mimics Rhematoid arthritis in adults

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4
Q

Parvovirus

A

Childern: Aplastic crisis in sickle cell disease, Erythema infectiosum (Fifth disease), Hydrops fetalis, Adults: pure RBC aplasia, RA-like symptoms

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5
Q

Parvovirus

A

Attaches RBC via blood group P-antigen; adult bone marrow (BM) and fetal liver principal targets;
Replicates in BM

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6
Q

Polyoma: JC virus

A

Progressive Multifocal Leukoencephalopathy (PML) in HIV; cytoplasmic inclusions in oligodendrocytes

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7
Q

Polyoma: BK viruses

A

Transplant patients; Targets Kidney- Hemorrhagic cystitis

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8
Q

Poxvirus: Vaccinia

A

Cowpox (Milkmaid’s blisters)

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9
Q

Poxvirus

A

Molluscum contagiosum- flesh-colored dome lesions with central dimple

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10
Q

CMV

A

AIDS retinits, Transplant recipients, Blood transfusion

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11
Q

CMV

A

Require initial contact with GAG chains on host cell surface proteoglycan for entry

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12
Q

Mononucleosis-like syndromes (monospot -ve)

A

CMV, HHV-6, toxoplasmosis

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13
Q

Virion/Virion-protein binding to cell surface receptors specificities

A

1) HIV gp120 and CD4 (CCR5/CXCR4).
2) EBV gp350 and CD21 (CR2).
3) Parvovirus B19 and Erythrocyte P-antigen
4) CMV and cellular integrins
5) Rabies and nAChRs
6) Rhinovirus and ICAM-1 (CD 54)

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14
Q

Naked, double stranded, RNA, segmented

A

Reoviruses: Rotavirus and Coltivirus

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15
Q

Coltivirus

A

Colorado tick fever

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16
Q

Rotavirus

A

1 cause of fatal diarrhea in children

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17
Q

Naked, +ssRNA, nonsegmented

A

Picornaviruses (PEECoRnA: Polio, Echo, Coxsackie, Rhino, HAV), Calicivirus, Hepevirus (HEV).

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18
Q

Negative stranded RNA viruses

A

Always Bring Polymerase Or Fail to Replicate: Arenavirus, Bunyavirus, Paramyxovirus, Orthomyxovirus, Filovirus, Rhabdovirus

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19
Q

Segmented viruses (BOAR)

A

Bunyavirus, Orthomyxovirus, Arenavirus, Reovirus

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20
Q

All segmented viruses are -ssRNA viruses, except–

A

Reovirus (dsRNA)

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21
Q

All -ssRNA are linear except–ABD

A

Arenavirus, Bunyavirus, Deltavirus (HDV) are circular

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22
Q

All -ssRNA virus capsids–

A

Helical

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23
Q

All +ssRNA and dsRNA (Reovirus) capsids are–

A

Icosahedral, except Coronavirus (Helical)

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24
Q

Genetic Shift

A

Reassortment- segmented genome undergo high-frequency recombination- pandemic

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25
Q

Genetic drift

A

Random mutations- epidemic

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26
Q

Picornaviruses

A

All are enteroviruses, except Rhinovirus

27
Q

Congenital Rubella

A

Intrauterine infection- Head: microcephaly, mental retardation; Ear: Sensorineural deafness; Eye: cataract (white pupil); Heart: PDA or peripheral pulmonic stenosis

28
Q

Rubella

A

Polyarthritis/Polyarthralgia in mother

29
Q

Paramyxoviruses

A

Parainfuenza, Mumps, Measles, RSV

30
Q

Paramyxoviruses

A

All contain surface protein F: causes respiratory epithelial to fuse and form multi-nucleated cells.

31
Q

Palivizumab (monoclonal Ab against F protein)

A

prevents pneumonia in premature infants due to paramyxovirus infection (RSV)

32
Q

Mumps- POM

A

Parotitis, Orchitis (infertility), aseptic Meningitis

33
Q

Rabies

A

binds to nAChRs- receptor-mediated endocytosis

34
Q

HCV

A

Flavivirus (unenveloped, +ssRNA, non-segmented)

35
Q

HCV

A

High mortality in pregnant mothers

36
Q

HCV

A

lymphoid aggregates within portal tracts and focal areas of macrovesicular steatosis

37
Q

HBV acute infection

A

HBsAg+, HBeAg+, anti-HBcAg-IgM+

38
Q

Window period

A

+ve anti-HBcAg-IgM: more specific marker for acute HBV

39
Q

HBsAg+ > 3 months

A

increase likelihood of chronic hepatitis B

40
Q

IgG-anti-HBc +

A

recovery from disease

41
Q

HBsAg+ > 6 months

A

Carrier state

42
Q

Chronic HBV (high infectivity)

A

HBsAg +, HBeAg +, IgG-anti-HBc +

43
Q

Chronic HBV (Low infectivity)

A

HBsAg +, anti-HBeAg +, IgG-anti-HBc +

44
Q

Recovery

A

anti-HBsAg +, anti-HBeAg +, IgG-anti-HBc +

45
Q

Immunized

A

anti-HBsAg antibodies only

46
Q

HBsAg

A

spherules and tubules 22 nm diameter of HBsAg in hepatocellular cytoplasm- finely granular, eosinophilic “ground glass” appearance of cytoplasm

47
Q

HIV: 3 structural genes

A

env, gag, and pol

48
Q

env

A

polyprotein product of env gene glycosylated to gp 160 and proteolytically cleaved in ER and Golgi to gp120 and gp41.

49
Q

gp120

A

binds to CD4 and CXCR4 or CCR5: attachment to host T cell

50
Q

gp41

A

fusion and entry

51
Q

gag

A

capsid protein: p24

52
Q

pol

A

reverse transcriptase, integrase, proteases

53
Q

HIV: 6 regulatory genes

A

tat, rev, nef, vif, vpr, vpu

54
Q

tat

A

transcriptionally activates other genes and contributes to HIV virulence

55
Q

rev

A

facilitates transport of unspliced viral transcripts out of nucleus

56
Q

nef

A

enhances replication by down-regulating CD4 and MHC-I expression

57
Q

HIV-associated encephalopathy

A

microglial nodules and multi-nucleated giant cells

58
Q

HIV +ve, superficial vascular proliferation, biopsy- neutrophilic inflammation

A

Bartonella henselae (bacillary angiomatosis)

59
Q

HIV +ve, superficial vascular proliferation, biopsy- lymphocytic inflammation

A

HHV-8 (Kaposi’s sarcoma)

60
Q

Congenital CMV

A

Deafness, seizures, petechial rash, blueberry-muffin rash

61
Q

Congenital syphilis

A

Notched teeth (Hutchinson’s teeth), saddle nose, short maxilla, saber shin, CN VIII deafness, hemorrhagic rhinitis

62
Q

Congenital HSV-2

A

Temporal encephalitis

63
Q

Coxsackievirus type A

A

Hand-Foot-Mouth disease- vesicular rash on palms and soles; myocarditis

Microbiology (13 decks)

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