Viruses And Viral Diseases Flashcards

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1
Q

Define transformation in reference to viruses. Name some examples.

A

The cell transforms into a tumor cell, such as HPV, HBV and HCV.

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2
Q

Define lytic in reference to viruses. Name some examples.

A

The cell dies and releases the virus, such as HSV and rhinovirus.

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3
Q

Define persistent infection in reference to viruses. Name some examples.

A

There is a slow release of virus without cell death, such as chronic hepatitis and HIV.

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4
Q

Define latent infection in reference to viruses. Name some examples.

A

The virus is present but is not causing harm to the cell; it later emerges in a lytic infection, such as HSV, HIV and chicken pox.

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5
Q

What is a relative of Ebola?

A

Filovirus.

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6
Q

What is the diameter of the filovirus?

A

80nm.

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7
Q

What is the length of the filovirus?

A

Around 14,000nm.

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8
Q

Does Ebola have a ssRNA negative sense genome?

A

Yes.

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9
Q

Is Ebola segmented or non-segmented?

A

Non-segmented.

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10
Q

Is Ebola enveloped or non-enveloped.

A

Enveloped.

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11
Q

How many nucleotides does Ebola contain?

A

19,000.

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12
Q

How many proteins does Ebola contain?

A

7.

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13
Q

What does Ebola cause?

A

Ebola haemorrhagic fever.

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14
Q

What type of pathogen is Ebola.

A

Cat 4 pathogen.

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15
Q

State three ways of human to human transmission.

A
  1. Blood.
  2. Mucosal surfaces and skin abrasions.
  3. Direct internalisations (injections).
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16
Q

What are the three types of immune cells that Ebola targets? Infection of these cells causes what?

A

Monocytes, macrophages and dendritic cells. Infection activates these cells and the infection moves to the spleen, liver and lymph nodes.

17
Q

Does Ebola infect lymphocytes?

A

No.

18
Q

What is the organ specific cell that Ebola targets?

A

Hepatocytes.

19
Q

Does Ebola target epithelial and endothelial cells?

A

Yes.

20
Q

Does Ebola target the extracellular matrix and collagen?

A

Yes.

21
Q

How long is the incubation period for Ebola?

A

2 to 21 days.

22
Q

What are the first four symptoms of Ebola?

A

Fever, chills, malaise and myalgia.

23
Q

What is the gastrointestinal systemic infection symptoms?

A

Anorexia, diarrhoea and vomiting.

24
Q

What is the respiratory systemic infection symptoms?

A

Chest pain.

25
Q

What is the vascular systemic infection symptoms?

A

Hypotension and oedema.

26
Q

What is the neurological systemic infection symptoms?

A

Headache, confusion and coma.

27
Q

Haemorrhagic conditions appear at peak of infection. What are the five results that occur?

A
  1. Petechiae.
  2. Collagen destroyed.
  3. Muscosal haemorrhaging.
  4. Epithelial layers sloughed off.
  5. Coagulopathy supervene.
28
Q

During days 6 to 16 of the Ebola infection, what occurs?

A

Hypovolaemic shock and multiorgan failure.

29
Q

What are the four reasons as to why there isn’t a vaccine for Ebola?

A
  1. Infection is rare.
  2. It’s costly.
  3. Health systems are weak due to civil wars.
  4. Vaccine needs to be successful in non-human primates.
30
Q

What are the three current available treatments for Ebola?

A
  1. Maintain oxygen and blood pressure.
  2. Provide IV fluids and electrolytes.
  3. Treat opportunistic infections.
31
Q

How many months did it take to characterise the Marburg virus?

A

Three months.

32
Q

Where was the Chikungunya fever virus first isolated?

A

In Tanzania in 1953.

33
Q

Is the Chikungunya fever virus ssNS RNA or ssPS RNA?

A

ssPS RNA.

34
Q

What family does the Chikungunya fever virus belong to?

A

Alphaviruses or Togaviridae.

35
Q

What are the three symptoms of Chikungunya fever virus?

A
  1. Sever fever.
  2. Myalgia of the legs.
  3. Crippling joint pain.
36
Q

Why can’t mosquitoes transmit HIV?

A

HIV cannot survive within a mosquito.

37
Q

Define hepatitis C virus (HCV).

A

It is 5% hepatocelluar carcinoma.

38
Q

Define human papillomavirus (HPV).

A

Cervical cancer and genital warts.