Viruses And Global Health

Question 1

Describe how emerging infectious viruses work

Answer 1

• Virus -> Acute infection: Entry, primary replication, spread, secondary rep, tissue damage, shredding
• Goes to either Viral strategies or immune strategies
• Viral strategies: Rapid replication, Immune evasion & Subversion, immune privilege, tissue damage, viral adaptation
• Immune strategies: Innate immunity, Antigen presentation, cytokines, Clonal expansion of lymphocytes, Antiviral effector mechanisms, Regulatory cell interaction
• VD

Question 2

What is the estimated burden of chronic viral infection in humans

Answer 2

• Chronic Global burden involves;
• Large DNA viruses – Herpes (HSV, CMV, EBV, KSHV, HHV-6, HHV-7)
• Small DNA viruses – Papilloma, Polyoma
• Unknown DNA viruses – Anellovirus
• Hepatitis – HCV, HDV
• Retrovirus – HIV, HTLV

Question 3

List the causes of acute infection

Answer 3

H1-16 causes H3, H7, H4, H7, H13, H5, H7, H9, H1-3, H1, H3, H5, H7,
Random bullshit VD

Question 4

Whole lectures BS