Viruses

Question 1

Viruses with segmented genomes

Answer 1

• Orthomyxoviruses (influenza)
• Reovirus
• Bunyavirus
• Arenavirus

Question 2

Function of early mRNA in viral replication

Answer 2

Synthesis of proteins to:

• Shut off host cell
• Replicate viral genome (if needed)

Question 3

Infection type of naked viruses

Answer 3

Cytolytic

Question 4

DNA viruses whose DNA is not linear

Answer 4

• Papilloma
• Polyoma
• Hepadnavirus (partial)

Question 5

Sign that helps distinguish rubella from other childhood rashes

Answer 5

Posterior auricular lymphadenopathy

Question 6

Antiviral agent that can cause leukopenia and thrombocytopenia

Answer 6

Ganciclovir

Question 7

When is HAART initiated

Answer 7

• CD4 count less than 350

* AIDS-defining illness

Question 8

Adverse effects of protease inhibitors

Answer 8

• Hyperglycemia
• Cytochrome inhibitors
• Thrombocytopenia
• Lipodystrophy

Question 9

Infectious naked viruses

Answer 9

dsDNA viruses (except poxvirus and HBV) and positive strand ssRNA

Question 10

Pathology in which you can find Guarneri’s bodies

Answer 10

Smallpox

Question 11

Adenovirus serotypes that can lead to pneumonia

Answer 11

4, 7, and 21

Question 12

Serotypes included in the adenovirus vaccine

Answer 12

4 and 7

Question 13

Adenovirus serotypes that can lead to gastroenteritis

Answer 13

40 and 41

Question 14

HPV protein that inhibits p53

Answer 14

E6

Question 15

HPV protein that inhibits Rb

Answer 15

E7

Question 16

Incidence of congenital CMV in the US

Answer 16

1/100 live births

Question 17

Mechanism of action of imiquimod

Answer 17

Stimulates TLR7 and secretion of TNF alpha

Question 18

Receptor for CMV

Answer 18

Integrins (heparan sulfate)

Question 19

RNA viruses with a double icosahedral capsid

Answer 19

Reoviruses

Question 20

Picornaviruses

Answer 20

“PEECoRnAviruses”

• Poliovirus
• Echovirus
• Enterovirus
• Coronavirus
• Rhinovirus
• HAV

Question 21

Norovirus belongs to which viral family

Answer 21

Calicivirus

Question 22

Reservoir for eastern equine encephalitis virus

Answer 22

Birds

Question 23

Chikungunya virus belongs to which viral family

Answer 23

Togavirus

Question 24

Councilman bodies are seen in which viral infection

Answer 24

• Yellow fever

* HAV

Question 25

Characteristic cells found in measles

Answer 25

Warthin-Finkeldey giant cells (fused lymphocytes)

Question 26

Geographic region of hantavirus

Answer 26

Four courners region (Utah, Arizona, New Mexico, Colorado)

Question 27

Biopsy findings in HCV infection

Answer 27

Lymphoid aggregates with focal areas of macrovesicular steatosis

Question 28

Gene product of HIV that downregulates class 1 MHC expression and upregulates FasL

Answer 28

Nef

Question 29

Gene product of HIV that inhibits cytokine synthesis and binds to genome and promotes transcription

Answer 29

Tat

Question 30

When should PCR be used in HIV patients

Answer 30

* Neonates * Indeterminate results * Acute infection in patient probably in window period * Screening for blood donors

Question 31

Difference in CNS lesions in HIV patients between EBV and Toxoplasma

Answer 31

EBV is usually a solitary ring-enhancing lesion (vs Toxo, multiple)

Question 32

Antibiotic prophylaxys for AIDS patients to prevent MAC infections

Answer 32

Clarithromycin/azithromycin

Question 33

Type of virus that produces a large polypeptide chain and then cleaves its protein products

Answer 33

Picornavirus