Bacteria Flashcards
Bacteria that lacks muramic acid in its cell wal
Chlamydia
Salmonella subspecies that does not produce H2S
Typhi
Factors that rickettsiae need for growth
- CoA
* NAD
Penicillin used from gram positive bacteria and gram negative rods
Ampicillin, amoxicillin
Cephalosporins that cover only gram positive organisms and are used for surgery prophylaxis
First generation cephalosporins
Cephalosporins that apart from gram positives, cover gram negatives also
Second generation cephalosporins
Cephalosporins that have very low gram positive coverage but a great gram negative coverage
Third generation cephalosporins
Third generation cephalosporin that covers Pseudomonas
Ceftazidime
Examples of first generation cephalosporins
- Cefazolin
* Cephalexin
Examples of second generation cephalosporins
- Cefotetan
- Cefoxitin
- Cefaclor
Examples of third generation cephalosporins
- Ceftazidime
- Cefotaxime
- Ceftriaxone
Cephalosporins that have as much gram positive coverage as first generation cephalosporins but less gram negative coverage than third generation, also covers Pseudomonas
Fourth generation
Fourth generation cephalosporin
Cepefime
Antibiotics that increase nephrotoxicity of aminoglycosides
Cephalosporins
Aztreonam coverage
Gram negatives only
Vancomycin coverage
Gram positives only
Aminoglycoside coverage
Gram negative aerobic rods
Metronidazole coverage
- Flagellates
* Anaerobes, below the diaphragm
Mechanism of action of isoniazid
- Inhibits synthesis of mycolic acid
* Needs catalase to activate
Mechanism of action of rifampin
Inhibits DNA-dependent RNA polymerase
Mechanism of action of ethambutol
Inhibits synthesis of arabinogalactan
Drugs that are inactivated by microbes by acetylation
- Aminoglycosides
* Chloramphenicol
Drug resistance mechanism of sulfonamides
Active export out of the cell
Drug resistance mechanism of vancomycin
Ligase produces D-ala-D-lactate, which doesn’t bind the drug
Bacteria with a poly-D-glutamate capsule
B. anthracis
Conjugated pneumococal vaccine
PCV13