Viruses Flashcards

1
Q

The two common types of DNA viruses are…

A

Phage T4 (virulent) & Lambda (temperate)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Virulent phage follow a _________ pathway, resulting in the ________ of the cell.

A

lytic; lysing

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Temperate phage can follow either a _________ pathway or a _________ pathway (which results in a period of ___________)

A

lytic; lysogenic; dormancy

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Resources plentiful: ________

Resources scarce: _________

A

lytic; lysogenic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Cells affected by phage in lysogeny that were permanently altered and are now life threatening diseases:

A
  1. Scarlett fever
  2. Diphtheria
  3. Botulism
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

A phage in lysogeny is sometimes called a …

A

Prophage

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

DNA polymerases…

A

make DNA

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

RNA polymerases…..

A

(with primase) make RNA

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

What RNA viruses need which is either brought along with them or immediately synthesized:

A

Replicase/Viral RNA Pol/Viral Replicase which is an RNA dependent RNA synthesizing enzyme

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Three main flavors of RNA viruses

A
  1. (+) sense strand
  2. (-) sense strand
  3. Retroviruses
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Nucleid acid synthesis, whether in the living or viral world, produced an ________________,_____________ molecule.

A

antiparallel, complementary

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Components of HIV

A

Viral protein, protease, integrase, receptor-binding glyctproteins, viral RNA, reverse transcriptase

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Reverse transcriptase

A
  1. RNA-dependent, DNA-synthesizing enzyme
  2. Degrades RNA component of RNA-DNA hybrid
  3. DNA-dependent, DNA-synthesizing enzyme (?)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

HIV has very limited range of host cell specificity…

A

…host cell must display CD4 molecule and have a co-receptor (chemokine family)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Example of cells that display CD4 molecule and co-receptor

A

T-cells in our immune system

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Molecule that can patch HIV into the host cell genome

A

Integrase is the tool HIV uses

17
Q

Integrase has an NLS and so….

A

When we non covalently attach it only the viral DNA, it can go right in

18
Q

How many bases are in the HIV genome?

A

9000

19
Q

HIV does not proofread and there is 1 mistake every 2000 base pairs so…

A

…changes about 4 times every time it gets replicated which makes it difficult to develop a resistant drug

20
Q

Viruses the enter via _________ use the drop in pH at the formation of the ___________ to trigger a conformation and escape into the cell.

A

endocytosis; early endosome