Viruses

Question 1

Whqt is the two importqnt human retroviruses

Answer 1

1. Human T cell lymphocyte virus

2. Human difeciency virus

Question 2

HTLV بتسبب مرضيين مهمين ايش همي؟

Answer 2

1 a cancer بنحكيله
Adult T cell leukemia or lymphoma and a
2. neurologic disease called ((HTLV associated myelopathy (( tropical spastic paraparesis or chronic progrssive myelopathy

Question 3

HIV and HTLVبيشتركو بانهم؟

Answer 3

Enveloped viruses

2. Reverse transcriptase in the virion
3. Two copies of a ss , positive polarity Rna geonme

Question 4

HIV and HTLVبيشتركو بانهم؟

Answer 4

Enveloped viruses

2. Reverse transcriptase in the virion
3. Two copies of a ss , positive polarity Rna geonme

Question 5

اوجه الاختلاف ما بين

HIV , HTLV

Answer 5

HTlV ما بيقدر يقتل الT cells بينما الhiv بيقتل
HTLV بتسبب malignant tanformation that immortalize the infected T cells andcallows them to proliferate in an uncontrolled manner .
يعني كانها بتضلها ملزقة بالTcell وبتخليها تتكاثر بطريقة غلط

Question 6

HTLV بينتقل عن طريق؟

Answer 6

IV drug use , sexual contact
Breast feeding
Transplacental transmission لكنها نادرة

Question 7

HTLV بينتقل عن طريق؟

Answer 7

IV drug use , sexual contact
Breast feeding
Transplacental transmission لكنها نادرة

Question 8

HTLV infection is endemic in certain geographic areas:

–

Answer 8

the Caribbean region, eastern South America, western

Africa, and southern Japan.

Question 9

كم معدل الseropositive adults لما قاسو الHTLV

Answer 9

Is as high as 20% in some of these areas , but infection can occure anywherr because infected indivisuals migrate to other pkaces

Question 10

AHL

Answer 10

Adult T cell leukemia
اول اشي الالفيروس بيهجم علىىالCD4positive T lymphocyte ورح ينتجلي
Malignant transformation
Uncontrolled growth charectersistic a cancer cell
وكل الT cell malignant تحتوي على تفس الintegrated proviral DNA
وبصيرله تكاثر وبيتكون عنا الmonoclonal
والHTLV بتضلها متخبية جوا ال تي سيل الخبيثة
يعني لا يتم انتاج الفيروس من اللخلية الخبيثة بس بتتخبى فيها

Question 11

HAM*(CHRONIC PROGRESSIVE MYELOPATHY))

Answer 11

Hamبصرله demyelenation disease of the brain and spunal cord (( motor neuron in Spinal cord))

Question 12

كيف ينتج الham

Answer 12

Autoimmune disease
Immune response against HTLV بتدمر اللعصاب
او
Cytotoxic T cells بتعمل على قتل الاعصصاب يلي مخببية فيها الفيروس

Question 13

ATL clinical finding

Answer 13

Lymphadenopathy , hepatosplenomegaly , lytic bone lesion , skin lesion (( proliferating Tcells infiltrating these organs

2. In the blood , the malugnant t cells have a distinict nucleus (( flower shaped
3. Reduced cell mediated immunity lead to opportunistic infectipns with fungi and viruses

Question 14

في ايش بيتشابه الATL, HAM

Answer 14

كل من الفيرزسن بيتطور اول اشي من دون اعراض ويتم الكشف عنه عن طريق ال Abs