Hepqtitis B Flashcards

1
Q

HBV من اي غيلة جاي

A

Hepadnavirus

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2
Q

شو خصائص الHBV

A

42 nm enveloped virus
2. Icosahedral nucleocapsid core
3 ds DNA((Circular))

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3
Q

HBVفي عندها عندها

3Ags

A
  1. HBsAg((surface antigenes))
    مهم لعملية التشخيص بالمختبر والimmunization
  2. HBcAg(( core))
    3.HBeAgكمان بيعتبروه موجود بالcore
    Soluble and is released from the infected cell to blood
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4
Q

الجينوم بيحتوي على ٤ جينات يلي بتعمل encode ل٥بروتينات

A

S genes encode surface ag
C gend encide core ag and e antigen
P gene encode polymerase
X gene encode X protein (HBx))

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5
Q

HBx ايش هوة

A

هوة عبارة عن activator لل viral RNA transcription وومكن ينوجد في الoncogenes لانه بيعمل على الinactivate the p53 tumor supresssor protein

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6
Q

في هاد الفيروس الDna polymeease يحتوي على شغلتين

A
  1. Rna depebdent(( reverse transcrpitase))

2. DNA dependent activity

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7
Q

The specifity of HBV for liver cell is based on 2 properites

A

1 virus specific receptor located on the hepatocyte mem to facilitqte the entry
2 trabscription factors found only in tge hepatocyte tgat enhance the viral mRna synthesis ( act post entry))

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8
Q

في ٣ طرق للنتقال

A

Blood
Sexually
Perinatally
Needle stick injury
منتشرة اكثر اشي عند الناس اللمدنمنين يلي بياخذو ابر وريدية
وخمسة وسبعين بالمية منتشرة باسيا
اذا اخذ المطعوم ضد هالفيروس بتقلل من حدوث الhepatoma in children

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