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From Molecules To Cells > Viruses > Flashcards

Viruses Flashcards

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Organic Chemistry 101 flashcards
1
Q

Cytopathic effect

A

Virus replication often damages infected cell

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2
Q

Susceptible cell

A

Has a functional receptor for a given virus, allowing the virus to enter

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3
Q

Resistant cell

A

Cell has no receptor

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4
Q

Permissive cell

A

Has the capacity to support virus replication

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5
Q

Poliovirus genome

A

Group IV = +ssRNA genome

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6
Q

Poliovirus structure

A

Iscosahedral

Non-enveloped

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7
Q

Poliovirus transmission

A

Faecal-oral

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8
Q

Poliovirus attachment

A 
CD155 receptor (cellular adhesion protein)
Interacts with viral capsid
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9
Q

Influenza virus genome

A

Group V = -ssRNA genome

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10
Q

Influenza structure

A

Spherical/ filamentous

Enveloped

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11
Q

Influenza transmission

A

Respiratory droplets, contact

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12
Q

Influenza attachment

A

Sialic acid receptor

Interaction with viral HA protein

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13
Q

HIV genome

A

Group 6: +ssRNA RT genome

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14
Q

HIV structure

A

Spherical enveloped

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15
Q

HIV transmission

A

Blood , sex , mother-> baby

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16
Q

HIV attachment

A

Attachment to CD4 receptor
Co-receptor = CCR5 / CXCR4
Interaction with viral gp120 & gp41 proteins

17
Q

VZV genome

A

Group I = dsDNA genome

18
Q

VZV structure

A

Complex + enveloped

19
Q

VZV attachment

A

Attachment to heparin sulfate proteoglycans
Receptor (?)
Interact with viral gb protein

20
Q

SARS- coronavirus 2 genome

A

Group IV= +ssRNA

21
Q

SARS structure

A

Spherical + enveloped

22
Q

SARS attachment

A

ACE-2 receptor

Interaction with viral spike protein

23
Q

SARS transmission

A

Airborne , contact

24
Q

Poliovirus entry

A

Non-enveloped

Receptor mediated endocytosis -> conformational change of virion = pore formed by VP1 = genome released into cytosol

25
Q

Influenza entry

A

Low pH dependent receptor mediated endocytosis

Acidification of endoscope triggers conformational change in viral HA protein -> mediates membrane fusion

26
Q

HIV entry

A

pH independent process = confirmation change in viral proteins -> mediates membrane fusion

27
Q

VZV entry

A

Receptor mediated fusion at plasma membrane

28
Q

SARS-CoV-2 entry

A

Receptor mediated endocytosis
Cellular protein TMPRSS2 cuts viral spike protein in specific places. Remixing spike protein undergoes conformational changes -> embedded in endosomal vesicle membrane -> virus envelope + vesicle membrane fuse, releasing genome into cytoplasm

From Molecules To Cells (2 decks)

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