Virus Assembly and Egress

Question 1

What are the 5 things a virus must be able to do to be successful?

Answer 1

Enter, express, replicate, assemble, egress

Question 2

What kind of virus(es) bud from the nuclear membrane?

Answer 2

Herpes Simplex Virus 1 (HSV-1)

Question 3

What kind of virus(es) bud from the plasma membrane?

Answer 3

Influenza and HIV

Question 4

What kind of virus(es) use apoptosis to escape the cell?

Answer 4

poliovirus

Question 5

Where does gene replication and assembly happen for poliovirus?

Answer 5

cytoplasm

Question 6

What are the target cells for Influenza?

Answer 6

Epithelial cells of respiratory system and alveolar macrophages

Question 7

What kind of genome does influenza have?

Answer 7

(-)ssRNA

Question 8

How do HA/NA get to the membrane?

Answer 8

They have hydrophobic signal sequences, and they are translocated through the ER to the Golgi and inserted into the PM

Question 9

What does protease do for NA/HA?

Answer 9

cleaves the long polypeptide

Question 10

What kind of antiviral drugs are Tamiflu and Relenza?

Answer 10

NA inhibitors

Question 11

What kind of virus has a diploid (+)ssRNA genome?

Answer 11

HIV