Immunity to Viral Infection

Question 1

What does the Jak/Stat pathway do?

Answer 1

inactivates protein translation, induces RNAse activity, destroys virus and host cell

Question 2

What activates the Jak/Stat pathway?

Answer 2

IFN a/B

Question 3

What happens if you don’t have any antibodies?

Answer 3

You get a bacterial infection

Question 4

What happens if you don’t have any T cells?

Answer 4

You get a viral infection

Question 5

What kind of immunity is most important for fighting viral infections?

Answer 5

T cell mediated immunity

Question 6

What is the major difference between C1MHC and C2MHC?

Answer 6

C1MHC is used to activate CD8 and C2MHC is used to activate CD4

Question 7

What happens when CD8 is stimulated?

Answer 7

CD8 proliferates and exits into the blood strea,

Question 8

What has to happen for a CD8 cell to become a CTL?

Answer 8

Must exit the node and start producing granules

Question 9

What activates the caspase pathway?

Answer 9

granzyme

Question 10

What is the back up method the CTL uses to kill a virally infected cell?

Answer 10

FasL on CTL binds to Fas on infected cell surface.

Question 11

What is IL-10 and how can viruses use it to their advantage?

Answer 11

IL-10 down regulates CTL activity, viruses ca steal IL-10 gene from host cells and use it down regulate CTL

Question 12

Why do CD8 cells rely on CD4 cells?

Answer 12

Because CD8 cells require IL-2 but they cannot produce it very well so CD4 produces most of the IL-2