Virulence Factor actions

Question 1

icam 1

Answer 1

allows binding to human cells

Question 2

capsule

Answer 2

prevents phagocytosis

Question 3

lipooligosacch

Answer 3

helps cells bind to non-ciliated epithelial cells

Question 4

fungal spores

Answer 4

phagocytes of IC not fast enough!

spores germinate and penetrate host tissue== necrosis :(

Question 5

hyaluronic acid capsule

Answer 5

prevents phagocytosis

Question 6

m protein

Answer 6

prevents phagocytosis

Question 7

Spe A-C, erythrogenic toxin A-C

Answer 7

damage capillary walls= scarlet fever

these toxins are super Ag that stim immune cells and cause toxic shock

Question 8

M protein in RHD

Answer 8

protein in antigenic and Bcells make Ab to m protein… these ab also react with heart proteins

Question 9

Diphtheria toxin

Answer 9

ADP ribosylation of host cell elgongation factor

Question 10

CX3CR1 or heparin sulfate

Answer 10

allows RSV to bind and infect human cells

Question 11

flu hemagglut and neuramindase

Answer 11

hemaglutt: bind to host cells
neuram: helps mature flu escape host cells

Question 12

Shift

Answer 12

change in type of H/N

Question 13

drift

Answer 13

mutation in H/N

Question 14

pertussis filamentous hemagglut

Answer 14

attachment to ciliated epithelial cells

Question 15

pertussis cytotox

Answer 15

kills cells that line trachea

Question 16

pertuss toxin

Answer 16

ADP ribosylating G protein, causes majority of tracheal cell damage

Question 17

myco plas cytadherence organelle

Answer 17

adhere to ciliated columnar epithelial airway cells

Question 18

pseudomonas alginate production

Answer 18

exopolysacch that allows binding to host cells. part of biofilm matrix which protects cells from phagocytosis