Virology Flashcards
Diagnosis of Rhinoviruses
Film array RT-PCR assay
Chikugunya Virus Genetic information
+ssRNA, enveloped
Long term consequences of West Nile Virus
Immunity or death (more neurologic disease in the elderly)
Basics of pathogenesis of Poliovirus
Vireia, invasion of the CNS, Lytic destruction of anterior horn cells
Vaccines and treatments for Parvovirus
Vaccine: None; Anti-viral therapy: Intravenous Ig for aplastic crisis in immunocompromised patients
Diagnosis of Helpes Siplex Virus II
Clinical presentation, PCR of infected tissue, culture virus from lesion
Vaccines and treatments for Hepatitis B Virus
Vaccine: Subunit vaccine; Anti-viral therapy: Nucleoside reverse transcriptase inhibitors (NRTIs)
Long term consequences of Rotavirus
Short-term immunity, less severe reinfection
Major disease associated with Hepatitis E virus
Hepatitis (developing world)
Vaccines and treatments for Rotavirus
Vaccine: Rotateq and Rotaric; Anti-viral therapy: None
Long term consequences of D68
Long-lived protective immunity
Transmission of HIV
Mother-to-child, transfusion, IV drug abuse, sexual
Diagnosis of Mumps Virus
Clinical , confirmed by serology or sequencing performed by public health department
Major disease associated with Ebolavirus
Hemorrhagic fever
Long term consequences of Cytomegalovirus
Latent infection with life-long shedding of virus, Sequelae in neonates
Major disease associated with Yellow Fever Virus
Yellow Fever
Transmission of Yellow Fever Virus
Mosquito bite (w/ urban cycle)
Vaccines and treatments for Hepatitis C virus
Vaccine: None; Anti-viral therapy: Direct acting anti-virals (DAAs)
Vaccines and treatments for Chikugunya Virus
Vaccine: None; Anti-viral therapy: None
Basics of pathogenesis of Rubella Virus
Replication in respiratory tract, viremia, rash
Basics of pathogenesis of Parainfluenza Virus
Local replication in respiratory tract, necrosis of epithelial cells
Transmission of Colorado Tick Fever Virus
Tick bite
Long term consequences of Molluscum Contagiosum
Long-term immunity, persistant in AIDS patients
Coxsackie Virus Genetic information
+ss RNA
Basics of pathogenesis of Molluscum Contagiosum
Painless lesions that take months to resolve
Basics of pathogenesis of Rotavirus
Local replication, enterotoxin production
Parainfluenza Virus Genetic information
-ss RNA, enveloped
Basics of pathogenesis of West Nile Virus
Viremia, CNS infection
Transmission of Influenza virus
Respiratory
Basics of pathogenesis of Colorado Tick Fever Virus
Verimia, inflamation and rash, recovery
Major disease associated with Hepatitis A Virus
Hepatitis
Major disease associated with HIV
Progress to AIDS
Diagnosis of Hepatitis E virus
Serology or RT-PCR by the public health department
Transmission of Dengue Virus
Mosquito bite
Long term consequences of Hantavirus
Long-term immunity and latency
Long term consequences of Poliovirus
Long-lived protective immunity or paralysis
Diagnosis of Measles Virus
Clinical , confirmed by serology or sequencing performed by public health department
Diagnosis of Colorado Tick Fever Virus
Serology by the public health department
Basics of pathogenesis of Smallpox virus
Viremia and rash
Diagnosis of Ebolavirus
RT-PCR from sera
Transmission of Helpes Siplex Virus II
Contact
Hepatitis B Virus Genetic information
Partial dsDNA, enveloped
Vaccines and treatments for Human Herpes Virus 6 & 7
Vaccine: None; Anti-viral therapy: None
Basics of pathogenesis of Yellow Fever Virus
Viremia, extensive replication and cell death in the liver
Long term consequences of Chikugunya Virus
Polyarthralgia can last weeks or months; recovery
Diagnosis of St Louis Encephalitis virus
RT-PCR and serology
Vaccines and treatments for Poliovirus
Vaccine: Live-attenuated oral and killed-virus injection; Anti-viral therapy: None
Major disease associated with Hepatitis Delta virus
Fulminant Hepatitis
Transmission of Mumps Virus
Respiratory (before the Parotitis)
Transmission of Coxsackie Virus
Fecal-oral
Long term consequences of HIV
Suseptability to oppertunistic infections, progression to AIDS, death
Basics of pathogenesis of Influenza virus
Local replication in respiratory tract, necrosis of epithelial cells
Major disease associated with Cytomegalovirus
Post-transplant pneumonia, Neonatal CMV
Helpes Siplex Virus II Genetic information
DNA, enveloped
Vaccines and treatments for Human Herpes Virus 8
Vaccine: None; Anti-viral therapy: None
Transmission of Chikugunya Virus
Insect vector
Basics of pathogenesis of Noroviruses
Lysis and shedding of epithelial cells
Basics of pathogenesis of Varicella-Zostar Virus
Replicates in respiratory epithelium, viremia, rash, latent in dorsal root ganglia, reaccurence as shingles can occur
Basics of pathogenesis of D68
Viremia leading to respiratory tract infection
Hepatitis E virus Genetic information
+RNA
Long term consequences of Hepatitis C virus
Hepatocellular Carcinoma
Vaccines and treatments for Rubella Virus
Vaccine: Live-attenuated vaccine, MMR; Anti-viral therapy: None
Basics of pathogenesis of Cytomegalovirus
Infects epithelium, cell proliferation, latency in Tc ells, macrophages, and other cells, sporadic shedding
Hepatitis Delta virus Genetic information
ss RNA viroid, enveloped
Vaccines and treatments for Hepatitis E virus
Vaccine: None (in trials); Anti-viral therapy: None
Diagnosis of Hepatitis Delta virus
Serology by antibody capture
Basics of pathogenesis of Rabies Virus
Replication in muscle, spread from nerves to brain
Major disease associated with Helpes Siplex Virus II
Genital lesions, Neonatal Herpes
Vaccines and treatments for Yellow Fever Virus
Vaccine: Live-attenuated; Anti-viral therapy: None
Transmission of Rubella Virus
Respiratory, Mother to Fetus
Long term consequences of Varicella-Zostar Virus
Latent infection with reacurrence as shingles
Yellow Fever Virus Genetic information
+ss RNA, enveloped
Diagnosis of Epstein-Barr Virus
Monospot (heterophile Ab) and/or serology for IgM to VCA
Major disease associated with Rubella Virus
“German Measles”
Long term consequences of Coxsackie Virus
Long-lived protective immunity
Long term consequences of Hepatitis B Virus
Hepatocellular Carcinoma
Diagnosis of Noroviruses
RT-PCR by film array
Transmission of EEE, WEE, and VEE
Mosquito bite
Vaccines and treatments for Hantavirus
Vaccine: None; Anti-viral therapy: None
Epstein-Barr Virus Genetic information
DNA, enveloped
Long term consequences of Coronavirus
Pandemic potential of emerging viruses like SARS and MERS, type specific immunity
Noroviruses Genetic information
+ss RNA
Major disease associated with Epstein-Barr Virus
Infectious mononucleosis
Long term consequences of Mumps Virus
Long-term immunity
Rhinoviruses Genetic information
+ RNA
Diagnosis of Varicella-Zostar Virus
Clinical presentation
West Nile Virus Genetic information
+ssRNA, enveloped
Diagnosis of Hepatitis C virus
RT-PCR, sequencing for genotype, serology
Basics of pathogenesis of Adenoviruses
Replication in epithelial cless, viremia
Transmission of Smallpox virus
Respiratory
Transmission of Poliovirus
Fecal-oral
Long term consequences of Rabies Virus
Immunity or Death
Poliovirus Genetic information
+ss RNA
Major disease associated with Hantavirus
Pulmonary syndrome
Diagnosis of Parainfluenza Virus
Clinical diagnosis or RT-PCR
Long term consequences of California Encephalitis Virus
Long-term immunity
Major disease associated with Respiratory Syncytial Virus
Severe lower respiratory tract infection in children
Basics of pathogenesis of Papilloma Virus
Virus production associated with cell differentiation
Diagnosis of West Nile Virus
RT-PCR and serology
Major disease associated with Colorado Tick Fever Virus
Fever and rash
Diagnosis of Yellow Fever Virus
Clinical diagnosis, confirmation by serology by public health department
Major disease associated with St Louis Encephalitis virus
Encephalitis
Vaccines and treatments for EEE, WEE, and VEE
Vaccine: For horses only; Anti-viral therapy: None
Transmission of Human Herpes Virus 6 & 7
Respiratory
Major disease associated with Parvovirus
Erythema Infectiosums (Fifth Disease)
Hepatitis C virus Genetic information
+ssRNA, enveloped
Diagnosis of D68
PCR and/or isolate virus and culture for cytopathic effect
Transmission of Cytomegalovirus
Contact: salivia, secretions, mother to newborn
HIV Genetic information
+RNA Lentivirus
Herpes Simplex Virus I Genetic information
DNA, enveloped
Major disease associated with Rhinoviruses
Common cold
Long term consequences of Yellow Fever Virus
Long-term immunity or death
Basics of pathogenesis of EEE, WEE, and VEE
Viremia, CNS infection
Major disease associated with Human Herpes Virus 8
Kaposi’s Sarcoma
Vaccines and treatments for Smallpox virus
Vaccine: Live-attenuated; Anti-viral therapy: None
Major disease associated with Human Herpes Virus 6 & 7
Roseola/ exanthem subitum
Long term consequences of Human Herpes Virus 6 & 7
Latent infection