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Microbiology And Parasitology PLE > Virology > Flashcards

Virology Flashcards

1
Q

The interstitial space between the nucleocapsid and the envelope

A

Tegument

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2
Q

All Viruses are haploid except

A

Retroviruses

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3
Q

One virus produces a protein that can be used by another virus

A

Complementation

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4
Q

Two different viruses infect the same cell

A

Phenotypic mixing

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5
Q

Gold standard in viral diagnosis

A

Presence of viral DNA or RNA

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6
Q

First vaccine known to prevent human cancer

A

HBV

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7
Q

All DNA viruses have double stranded DNA except

A

Parvovirus

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8
Q

All DNA viruses have linear DNA

A

Papilloma
Polyoma
Hepadna

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9
Q

All DNA viruses are icosahedral except

A

Poxvirus (complex)

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10
Q

All DNA viruses replicate in the nucleus except

A

Poxvirus (cytoplasm)

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11
Q

Naked DNA viruses

A

(HU-P-AD)

Parvovirus
Adenovirus
Human Papillomavirus

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12
Q

Etiology of Erythema Infectiosum

May also cause aplastic crisis, Hydrops fetalis, pancytopenia in chronic infection

A

Parvovirus B19

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13
Q

Only virus with fiber/penton

Known to cause hemorrhagic cystitis

Histopathology: Cowdry type B inclusions

A

Adenovirus

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14
Q

Infects squamous cells and induce formation of cytoplasmic vacuoles/koilocytes

A

Human Papilloma Virus (HPV)

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15
Q

Cause progressive multifocal leukoencephalopathy in patients with AIDS

Affects oligodendrocytes (deficits in speech, coordination and memory)

A

JC Polyoma Virus

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16
Q

Causes hemorrhagic cystitis and nephropathy in patients with kidney and bone marrow transplants

A

BK Polyoma Virus

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17
Q

Multinucleated giant cells seen on Tzank Smear

Large, pink to purple intranuclear inclusions (Cowdry type A)

A

Herpes Simplex Virus

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18
Q

All enveloped viruses acquire their envelope from plasma membrane except

A

Herpes Virus (nuclear membrane)

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19
Q

Site of latency of HSV1

A

Trigeminal ganglia

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20
Q

Site of latency of HSV 2

A

Lumbosacral ganglia

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21
Q

Site of latency of VZV

A

Dorsal root ganglia

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22
Q

Dewdrop on a rose petal appearance/vesicular centrifugal rash

A

Varicella

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23
Q

Painful vesicles along dermatomal distribution

Postherpetic Neuralgia

A

Varicella Zoster

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24
Q

Cultured in shell tubes
Heterophil-negative mononucleosis

HP: giant cells with owl’s eye nuclear inclusions

A

CMV

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25
Most common infectious cause of congenital abnormalities
Congenital CMV
26
Most common cause of blindness in HIB
CMV retinitis
27
Drug of choice for CMV
Ganciclovir
28
Infects mainly lymphoid cells, primarily B lymphocytes Heterophil-positive mononucleosis / Kissing Disease
EBV
29
EBV infectious mononucleosis most commonly occurs in
Young adults
30
Oral hairy leukoplakia among immunocompromised patients caused by infection of oral squamous epithelial cells with?
EBV
31
Magnancies associated with EBV
Burkitt's lymphoma Nasopharyngeal Carcinoma Hairy leukoplakia B-cell lymphoma
32
Malignancy of the vascular endothelial cells
Kaposi Sarcoma
33
Largest viruses Only disease eradicated from the face of the Earth Guarnieri bodies / intracytoplasmic eosinophilic bodies
Poxvirus
34
HP: Henderson-Peterson bodies Pinkish, papular lesion with umbilicated center Tx: Cifodovir
Molluscum Contagiosum
35
Only DNA virus that produces DNA by reverse transcription with mRNA as the template
HBV
36
Most specific marker for diagnosis of ACUTE HBV infection Persists during the window period
IgM anti-HBcAg
37
All RNA viruses have single-stranded RNA
Reovirus | Rotavirus
38
All RNA viruses replicate in the cytoplasm except
Influenza | Retrovirus
39
Replicates in motor neurons in the anterior horn of the spinal cord causing paralysis
Poliovirus
40
Virus known to cause Herpangina, Hand-Footh-Mouth Disease, Hemorrhagic conjuntivitis Most common cause of aseptic meningitis
Coxsackie Virus
41
known to cause common colds / runny nose
Rhinovirus
42
Also known as Enterovirus 72
Hepatitis A Virus
43
Most common cause of nonbacterial diarrhea in adults Sudden onset of vomiting and diarrhea accompanied by fever and abdominal cramping
Norwalk Virus / Norovirus
44
Most common cause of childhood diarrhea
Rotavirus
45
Most common cause of respiratory tract infections
Influenza virus
46
Major antigens of influenza virus
Hemagluttinin | Neuraminidase
47
Sudden change based on the reassortment of segments of genome RNA producing new strains Causes pandemics
Antigenic Shifts
48
Slow and progressive changes based on mutations in the genome RNA Causes epidemics
Antigenic Drifts
49
Drug of choice for influenza
Oseltamivir | Zanamivir
50
Infects a host cell inducing cell membranes of adjacent cells to fuse into large multinucleated giant cells or syncitia
Paramyxovirus
51
Cardinal manifestation of Measles
Cough Coryza Conjunctivitis
52
Causes tender swelling of the parotid glands
Mumps Virus
53
Most important cause of pneumonia and bronchiolitis in infants Tx: Ribavirin
Respiratory Syncitial Virus
54
Causative agent of Laryngotracheobronchitis (Croup)
Parainfluenza
55
Bullet shaped enveloped virus; Transmitted via animal bite Multiplies locally at the bite site, infecting sensory neurons and moves by axonal transport to CNS HP: Negri Bodies
Rabies Virus
56
Enveloped RNA virus (Negative Sense)
Paramyxoviridae (Parainfluenza, RSV, Mumps, Measles) Rhabdoviridae (Rabies Virus) Orthomyxoviridae (Influenza)
57
Known to cause atypical pneumonia rapidly progressing to ARDS Chest x-ray: non-cavitary "groud-glass" infiltrates
Coronavirus
58
Gold standard in diagnosis of Dengue
Dengue PCR
59
Most prevalent blood-borne pathogen Main cause of essential mixed cryoglobulinemia
Hepatitis C Virus
60
Known to cause german measles Transmitted via respiratory droplet, transplacental
Rubella virus
61
PDA, Congenital cataract, sensorineural deafness, mental retardation, blueberry muffin baby
Congenital Rubella Syndrome
62
Only RNA virus with an the enzyme, reverse transcriptase
Retrovirus
63
Definitive diagnosis of HIV
Western blot analysis
64
CD4 <500
M. Tuberculosis HSV C. Albicans HHV8
65
CD4 <200
``` P. Jirovecci T. Gondii C. Neoformans C. Immitis C. Parvum ```
66
CD4 <50
M. Avium H. Capsulatum CMV
67
Most common cause of epidemic Encephalitis Transmitted by Culex mosquitoes
Japanese B Virus

Microbiology And Parasitology PLE (2 decks)

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