Parasitology Flashcards
Psuedopod-forming nonflagellated protozoa: brownian movement
Entamoeba histolytica
Entamoeba histolytica
Infective stage:
Diagnostic Stage:
DOC:
Infective stage: mature cyst
Diagnostic Stage: wet stool - trophozoite; solid stool - cysts
DOC: Diloxanide Furoate
Dysentery without fever
Flask-shaped colon ulcers
Entamoeba histolytica
Flagellate that lives in the small intestine
Falling leaf motility
Gardia Lamblia
Giardia Lamblia
Infective stage:
Diagnostic Stage:
DOC:
Infective stage: cysts
Diagnostic Stage: trophozoites, cysts
DOC: metronidazole
Acute: Abdominal pain, diarrhea, excessive flatus (rotten egg)
Chronic: constipation, weight loss and steatorrhea
Giardia Lamblia
Opportunistic intestinal protozoa
Undergoes schizogony and gametogony
Autoinfection in immunicompromised patients
Self-limited nonbloody diarrhea
Cryptosporidium Parvum
Cryptosporidium Parvum
Infective stage:
Diagnostic Stage:
DOC:
Infective stage: thick-walled oocysts
Diagnostic Stage: thick-walled oocysts
DOC: Nitazoxamide - immunocompetent; HAART - immunocompromised
Urogenital protozoan
Exists only as a trophozoite
Pear-shaped flagellated trophozoites
Trichomonas Vaginalis
Trichomonas Vaginalis
Infective stage:
Diagnostic Stage:
DOC:
Infective stage: trophozoites
Diagnostic Stage: trophozoites
DOC: metronidazole
Watery-foul smelling greenish vaginal discharge accompanied with itching and burning
Strawberry Cervix
Trichomonas Vaginalis
Blood and tissue protozoa
Asexual life cycle: schizogony and gametogony
Sexual life cycle: sporogony
Plasmodium
Plasmodium
Infective stage:
Diagnostic Stage:
Infective stage: sporozoites
Diagnostic Stage: trophozoites
Malignant tertian
Asexual cycle of 48hours
Banana-shaped gametocytes
Causes cerebral malaria
P. Falciparum
Benign tertian Asexual cycle of 48hours Large round gametocytes Rbc preference: young RBCs With relapse
P. Vivax
Benign tertian Asexual cycle of 48hours Small round gametocytes Rbc preference: young RBCs With relapse
P. Ovale
Benign quartsn Asexual cycle of 72hours Compact gametocytes Rbc preference: old RBCs With recrudescence
P. Malariae
Recurrence of symptoms after a temporary abatement
P. Falciparum and P. Malariae
Recrudescence
Return of a disease after its apparent cessation due to reactivation of hypnozoites
P. Ovale and P. Vivax
Relapse
Used to screen for the presence of organisms in Malaria
Thick Smear
Used for species identification in Malaria
Thin smear
Punctate granulations present in RBCs invaded by P. Ovale and P. Vivax
Schuffner Dots
Coarse granulation present in RBCs invaded by P. Falciparum
Maurer Dots
Fine dots present in RBCs invaded by P. malariae
Ziemann Dots
DOC for P. vivax and P. Ovale
Chloroquine plus Primaquine
Toxoplasma Gondii
Definitive host: cats
Infective stage:
Diagnostic Stage:
DOC:
Infective stage: fecal oocyst
Diagnostic Stage: trophozoite (bradyzoite)
DOC: sulfadiazine plus pyrimethamine
Blood and tissue protozoan
Transmitted by reduviid bug
Cardiac muscle is the most frequently and severely affected tissue
Trypanosoma Cruzii
Trypanosomia Cruzi
Infective stage:
Diagnostic Stage:
DOC:
Infective stage: metacyclic trypomastigotes
Diagnostic Stage: trypomastigotes in blood
DOC: nifurtimox
Blood and tissue protozoan
Remarkable antigenic variation
Transmitted by: Tsetse fly
Trypanosoma Brucei
Trypanosoma Brucei
Infective stage:
Diagnostic stage:
Infective stage: metacyclic trypomastigotes
Diagnostic Stage: trypomastigotes in blood
Primary amebic meningiencephalitis
Acquired while swimming in contaminated pools
Naegleria fowleri
Only ciliated protozoan to cause human disease
Associated with pigs
Round based, wide necked intestinal ulcers
Balantidium coli
Transmitted by Ixodes tick
Intraerythrocytic ring shaped trophozoites in tetrads in the form of Maltese cross
Babesia Microti
Transmitted by sandfly/Phlebotomus
Infective promastigotes
Leishmania
Most common and largest intestinal nematode
Giant roundworm
Soil-transmitted helminth
Dx: kato-katz technique, direct fecal smear
Ascaris Lumbricoides
Ascaris lumbricoides Transmission: Infective stage: Diagnostic Stage: DOC:
Transmission: ingestion of eggs
Infective stage: embryonated egg
Diagnostic Stage: unembryonated egg
DOC: albendezole
Principal site of tissue reaction of Ascaris lumbricoides
Lungs (inflammation with an eosinophilic exudate)
Blood sucking nematode
Soil-transmitted
Causes microcytic anemia and hypoalbuminemia
Ground itch at site of entry
Necator Americanus
Ancylostoma duodenale
Necator americanus and Ancylostoma Transmission: Infective stage: Diagnostic Stage: DOC:
Transmission: larvae penetrate skin
Infective stage: filariform larvae
Diagnostic Stage: eggs in feces
DOC: albendazole
Whipworm
Soil-transmitted helminth
Kato-katz: barrel shaped eggs with bipolar plugs
Diarrhea may lead to rectal prolapse
Trichiuris trichiura
Trichiuris trichiura Transmission: Infective stage: Diagnostic Stage: DOC:
Transmission: ingestion of eggs
Infective stage: embryonated egg
Diagnostic Stage: unembryonated egg
DOC: mebendazole
Most common Soil transmitted helminth in developed countries
Pinworm; seatworm
Perianal pruritus
Life cycle is confined to humans
Graham scotch tape technique: D shaped eggs
Enterobius Vermicularis
Enterobius Vermicularis Transmission: Infective stage: Diagnostic Stage: DOC:
Transmission: ingestion or inhalation of eggs
Infective stage: embryonated egg
Diagnostic Stage: unembryonated egg
DOC: Pyrantel Pamoate
Facultative parasite; thread worm
Soil-transmitted helminth
Harada-Mori Culture
Penetrates intestinal wall directly without leaving host and migrates to the lungs
Strongyloides stercoralis
Strongyloides stercoralis Transmission: Infective stage: Diagnostic Stage: DOC:
Transmission: larvae penetrate skin
Infective stage: filariform larvae
Diagnostic Stage: rhabtidiform larvae
DOC: ivermectin
Onky nematode whose life cycle involves a migratory bird
Pudoc worm
Kato-katz: peanut shaped eggs with flattened bipolar plugs
Capillaria Philippinensis
Capillaria Philippinensis Transmission: Infective stage: Diagnostic Stage: DOC:
Transmission: undercooked fish
Infective stage: infective larvae
Diagnostic Stage: unembryonated egg
DOC: Albendazole
Most debilitating nematode infection
Blood and tissue nematode
Dx: Thick blood smear done at night between 8pm and 4pm
Wuchereria and Brugia
Smoothly curved Absent terminal nuclei preference: scrotal lymphatics Hydrocele More severe
Wuchereria Bancrofti
Kinky With terminal nuclei Preference: limb lymphatics Elephantiasis Less severe
Brugia Malayi
Wuchereria and Brugia Transmission: Infective stage: Diagnostic Stage: DOC:
Transmission: mosquito bite
Infective stage: 3rd stage larvae
Diagnostic Stage: microfilariae
DOC: diethylcarbamazine
Tissue nematode
Intermediate host: pigs
Dx: muscle biopsy - larvae within striated muscle
Trichinella Spiralis
Trichinella Spiralis Transmission: Infective stage: Diagnostic Stage: DOC:
Transmission: undercooked pork
Infective stage: encysted larvae
Diagnostic Stage: encysted larvae
DOC: thiabendazole
Known for causing Mazotti reaction, river blindness
Transmitted by female blackfly
DOC: Ivermectin
Onchocerca Volvulus
Oriental blood fluke
Reside in the mesenteric and portal veins
Intermediate host: snail (Onchomelania quadrasi)
Circumoval precipitin test: Ovoid egg with small hook
Schistosoma Japonicum
Schistosoma Japonicum Transmission: Infective stage: Diagnostic Stage: DOC:
Transmission: cercariae penetrate skin
Infective stage: cercariae
Diagnostic Stage: eggs in feces
DOC: praziquantel
Known for causing katayama fever, swimmer’s itch
Areas of endemicity: Sorsogon, Samar, Leyte, Oriental Mindoro, Bohol, all of mindanao except Misamis Oriental
Schistosoma Japonicum
Lungh fluke; Hermaphrodite
Intermediate host: snail (antemelania asperata); mountain crab (sundathelphusa philippina)
Dx: 3% NaOH - ovoid, thinner opercular end, thickened abopercular end
Paragonimus Westermani
Chronic cough with bloody sputum
Cxr: ring shadow opacity
Closely resembles tuberculosis
Develops fibrous wall that provokes a granulomatous reaction
Pragonimus Westermani
Paragonimus Westermani Transmission: Infective stage: Diagnostic Stage: DOC:
Transmission: undercooked crab meat
Infective stage: metacercariae
Diagnostic Stage: unembryonated egg
DOC: praziquantel
Asian liver flukes; hermaphrodite
Intermediate hosts: snail (prafossarulus), fish (cyprinidae)
Dx: potassium permanganate stain - ovoid with melon like ridges and abopercular protuberance
Clonorchis sinensis
Can cause hyperplasia and fibrosis of the biliary tract
Known to cause cholangiocarcinoma, neurocirculatory dystonia
Clonorchis Sinensis
Clonorchis Sinensis Transmission: Infective stage: Diagnostic Stage: DOC:
Transmission: undercooked crab meat
Infective stage: metacercariae
Diagnostic Stage: unembryonated egg
DOC: praziquantel
Intestinal cestodes are differentiated based in scolex and gravid proglottids
Taenia Solium: 5-10 Gravid Proglottids
Taenia Saginata: 15-25 Gravid Proglottids
Taenia Transmission: Infective stage: Diagnostic Stage: DOC:
Transmission: undercooked meat
Infective stage: cysticerci
Diagnostic Stage: gravid proglottids
DOC: praziquantel
Known to cause neurocysticercosis, worms in vitreous humor
Taenia solium
Fish tapeworm; broad tapeworm
Has two elongated sucking grooves for attachment
Have operculated eggs
Intermediate host: fish and copepods
Causes megaloblastic anemia
Diphylobothrium Latum
Diphyllobothrium Latum Transmission: Infective stage: Diagnostic Stage: DOC:
Transmission: undercooked fish
Infective stage: plerocoid larvae
Diagnostic Stage: unembryonated egg
DOC: praziquantel
One of the smallest tapeworm
Composed of scolex and only three proglottids
Intermediate host: sheep/man
Definitive host: dog
If cyst ruptures, may cause life threatening anaphylaxis
Echinococcus Granulosus
Echinococcus Granulosus Transmission: Infective stage: Diagnostic Stage: Treatment:
Transmission: ingestion of eggs
Infective stage: embryonated egg
Diagnostic Stage: hydatid cysts
Treatment:surgical resection, albendazole