Virology Flashcards
Typical size range of a virus
20 - 300 nm
Protein coat of all viruses
Capsid
*composed of repeating capsomeres
Nucleic acid genome + capsid = ?
Neucleocapsid
ALL helical viruses are enveloped, TRUE or FALSE?
TRUE
Virus that acquires its envelope from nuclear membrane (as o
Herpesviridae
Naked RNA viruses
Calicivirus, Picornavirus, Reovirus
Naked DNA viruses
Parvovirus, Adenovirus, Papillomavirus, Polyomavirus
Infectious particles composed entirely of proteins which are highly resistant to inactivation
Prions
All viruses are HAPLOID except ?
Retrovirus which is DIPLOID
Viruses with segmented genomes
Bunyavirus, Orthomyxovirus, Arenavirus, Reovirus
*BOAR
Negative stranded RNA viruses
Arenavirus, Bunyavirus, Paramyxovirus, Orthomyxovirus, Filovirus, Rhabdovirus
How many Phases are involved in a viral growth curve?
6
Phases 0 to 5
Phase in growth curve where no virus is detectable inside the cell
Phase 2 - Eclipse Phase
Phase in growth curve where a single virus particle infects the cell
Phase 0 - Entry
Phase in growth curve where there is a dramatic increase in amount of detectable virus
Phase 3 - Rise Period
Phase in growth curve where there is marked derangement of cell function leading to lysis and cell death
Phase 5 - Cytopathic Effect
Phase in growth curve where there is decrease in number but continuous function of both cell and virus
Phase 1 - Decline
Phase in growth curve where there is a detectable amount of virus which reaches a plateau
Phase 4 - Latent Period
Presence of IgM can mean _____ infection
Current/Acute
Live Attenuated Vaccines
Yellow Fever
Chicken Pox (VZV)
Sabin’s polio
MMR
Only live attenuated vaccine that may be given to HIV positive patients
MMR
Killed vaccines
Rabies
Influenza
Polio (Salk’s)
Hepatitis A
DNA viruses
Hepadna Herpes Adeno Pox Parvo Polyoma Papilloma
ALL DNA viruses have double stranded DNA except?
Parvovirus
ALL DNA viruses have linear DNA except?
Papillomavirus
Polyomavirus
Hepadnavirus
ALL DNA viruses are icosahedral except?
Poxvirus
ALL DNA viruses replicate in the nucleus except?
Poxvirus
*replicates in the cytoplasm
Mode of transmission of Parvovirus B19
Respiratory
Transplacental
Mode of transmission of Adenovirus
Respiratory
Fecal - Oral
Mode of transmission of HPV
Sexual Skin contact (break in barrier)
Virus associated with slapped cheeks, fever, coryza, sore throat with transient but severe aplastic anemia
Parvovirus B19
Fifth Disease
Only virus with fibers, with disease spectrum ranging from URTI to GIT and hemorrhagic cystitis
Adenovirus
