Virology Flashcards
Adenovirus
conjunctivitis, pharyngitis
dense basophilic intranuclear inclusion bodies
diarrhea in infant
infectious genome
icosadeltahedral capsid with fibers
poorly chlorinated swimming pools
Bunyaviruses
California encephalitis viruses: Celux mosquito, arbovirus, woods, LaCrosse virus, encephalitits, meningitis
Hantoviruses: hemorrhagic, petechiae, ecchymosis, bleeding tissues, rodent feces and urine
Coronaviruses
Common cold
SARS
Fecal-oral and respiratory spread
HSV
Enveloped, large, DNA, Cowdry type A inclusion bodies, neurotropic, Tzanck smear, multinucleated giant cells, stress-induced recurrence, encephalitis, destruction of temporal lobe, blindness, neonatal HSV
CMV
owl’s eye nuclear inclusion body
swollen cells
opportunistic disease
mononucleosis-like syndrome
congenital CMV
intracerebral calcifications microcephaly
Epstein-Barr Virus
Mononucleosis, fatigue, pharyngitis, heterophile antibody, atypical lymphocytes, rash, monospot test, ampicillin-induced rash
Varicella zoster virus
Crops of vesicular lesions
All stages of lesions at once
Vesicles, latency
multinucleated giant cells
Cowdry type A
nuclear inclusion bodies
Neurotropic
Thymidine kinase
Shingles
Chicken pox
Hepatitis A
Fecal-oral spread
Acute, sudden-onset hepatitis
day care center
food-borne
shellfish
picornavirus
Hepatitis E
Fecal-oral spread
Acute, sudden-onset hepatitis
Pregnant women
Norovirus
Hepatitis B
Serum hepatitis, chronic, Dane particle, insidious onset, HbsAg, hepadnavirus
Hepatitis C
Non-A, non-B hepatitis, chronic, flavivirus
Hepatitis D
Fulminant hepatitis, HBV helper virus
HIV
AIDS CD4 Chemokine coreceptor opportunistic disease: PCP, Kaposi’s sarcoma, C. albicans thrush, CMV retinitis, pneumonitis, reverse transcriptase
Parainfluenza virus
Croup, barking seal, pneumonia, syncytia, paramyxovirus
RSV
infant, bronchiolitis, paramyxovirus
Measles
Koplik’s spots (blue-gray spots in mouth) 3C’s + photophobia, high fever, rash Paramyxovirus
Norovirus
Parotitis: chipmunk cheeks
Orchitits pancreatitis and aseptic meningitis or encephalitls
(5%) paramyxovirus
Mumps
Parotitis: chipmunk cheeks Orchitits pancreatitis and aseptic meningitis or encephalitls (5%) paramyxovirus
Norovirus
Outbreaks of diarrheal disease
Nausea
Watery diarrhea and vomiting
schools
cruise ships
Orthomyxovirus
influenza segmented genome = reassortment hemagglutinin and neuraminidase antigenic drift (minor mutations) (outbreak/epidemic) vs shift (reassortment = pandemic)
Papillomovirus
warts, koilocyes, CIN, cervical cancer, STD
Polyomaviruses
JC, demyelination, abnormal oligodendrocytes, opportunistic disease, PML
Parvovirus B19
Fifth disease slapped cheek lacy pattern rash anemia
Coxsackie and ECHO viruses
Fecal-oral vesicular lesions Cosackie B for body Picornavirus
Poliovirus
Asymmetrical flaccid paralysis major disease minor disease Fecal-oral Picornavirus
Rhinovirus
Runny nose, many serotypes, heat and pH labile, picornavirus
Poxviruses
Large-brick shaped virus Replicates in cytoplasm vesicular lesion zoonosis molluscum contagiosum: skin-colored papules smallpox: synchronized crop of vesicular lesions (smallpox), vaccinia vaccine
Prions
Spongiform encephalopathy, CJD, vCJD, beef, no inflammation, presenile dementia, shakes, resistant to inactivation
Rabies
Dog bite bats aerosol hydrophobia coma salivation Negri bodies Rhabdovirus
Rotavirus
Watery diarrhea in young child Double capsid and double-stranded segmented RNA
Rubella
Rash, vaccine, congenital disease, arthritis, eratogen, cataracts, togavirus
Togavirus
Arbovirus Encephalitis viruses: mosquito, seasonal encephalitis, swamps Hemorrhagic viruses: blood everywhere, petechiae
Flavivirus
Arbovirus Encephalitis viruses: mosquito, seasonal encephalitis, swamp Hemorrhagic viruses: blood everywhere, petechiae
