Virology Flashcards
What is a matured virus called?
Virion
A virus varies from …………… to …………. in size
20 nm to 300 nm
The genome of a virus can exist in the following forms
Segmented
Circular
Linear
Double stranded
Single stranded
What is the subunit of a capsid
Capsomere
Most human helical virus are …………
While hecosahedral are either ………….. or ………
Enveloped
Either enveloped or non enveloped
Examples of ds DNA viruses
Adenovirus
Pox virus
Papilloma virus
Herpes virus
Rhino virus belongs to …………….
+sense RNA viruses and it is the major cause for common cold
List the functions of capsids
Vehicle of transmission from one host to the other
Binding site for virus
Protection
Structural symmetry
Antigenicity
It facilitates assembly and packaging of viral genetic information
The four families that gave a subgroup are
Herpesviridae
Poxviridae
Parvoviridae
Paramyxoviridae
The subdivision in a family are called
Genera
List the steps involved in the pathogenesis of virus
What is viral clearance and shedding
Viral clearance is the persistence of viral infection in a host
Vital shedding is the exit of a virus from the host where it’s replicating, into the environment in order to affect other host
HSV and papilloma virus are transmitted in the urogenital area through local lesions while othe viruses such as ……….. ………….. …….. do not cause local lesion
HIV 1 and 2
HTLV 1 A and 2
Hepatitis B and C
Disease that can be caused by entry of virus through the eye( Conjunctiva, cornea)
Conjunctivitis ( adenovirus, arenavirus)
Keratitis( herpes simplex)
The protein molecules that a virus bind to on the cell surface can be ……..
………..
……….. depending on their role
Receptor
Co receptor
Attachment factors
Entry factors
What is receptor mediated endocytosis
This is a process by which cell receptors bound to their ligands are enclosed into clarithin coated vesicles or caveolae ( endosomes)
The commonly used mechanism by virus for penetration is
Receptor mediated endocytosis
Fusion is the penetration mechanism commonly used by ………..
Enveloped virus
The mechanism commonly used by virus with and without envelope are …………. and ……………… respectively
Apoptosis
Budding ( this is the most common process by which a virus gets its envelope)
Non enveloped virus mature in the cell within …………… and ……………
Cytoplasmic ( picornaviruses)
Nucleus( adenovirus)
Where do the enveloped virus mature
At the cell membrane at the point of exit
Receptor molecules for viruses are generally
Glycoprotein
Example of virus released as free nucleic acid is
Picornaviruses
Viruses released as nucleocapsid are
Reovirus
