Virology Flashcards
Intracellular organisms unable to reproduce itself outside the host cell
virus
All viruses are haploid except for
RETROVIRUS
Virus multiplies by binary fission
True or False
False
entire infectious unit of virus
virion
internal core of virus
genome
protein coat that surrounds the genome
capsid
Subunits of capsid are called
CAPSOMERES
Type of capsomeres
icosahedral
helical
complex
Virus without envelope are classified as
NAKED
Viruses are resistant to
antimicrobial
antibacterial
Viruses can survive long periods at
-70degC when freeze dried
Viruses can be killed with ____ but are somewhat resistant to _____
moist heat
dry heat
These inactivates viruses
UV and XRAY irradiation
Inactivate viruses that have lipid envelope
Chloroform
Ether
Protein shell or coat that encloses the nucleic acid genome that is built
of structural units of a virion
Capsid
DNA (deoxyribonucleic acid) or RNA (ribonucleus acid)
Nucleic Acid
Nucleic acid + Capsid (Enclosed)
Nucleocapsid
Morphological units seen on the surface of particles and represent
clusters of structure units or polypeptide
Capsomeres
A lipid containing membrane that surrounds some viral particles.
Envelope
A lipid containing membrane that surrounds some viral particles.
Envelope
It is acquired during viral maturation by a budding process through a cell membrane
Envelope
Envelope viruses has a ______ appearance inside the envelope
pleomorphic
the smallest functional unit equivalent to building units of the capsid. Basic protein that acts as building blocks of the coat
Structural units- Protomers
Lysis is required for __________ and not for ___________
icosahedral pattern
helical pattern
the most efficient arrangement for subunits in a closed shell
Cubic symmetry
observed with animal viruses is the
icosahedral pattern
protein subunits are bound in a periodic way to the viral nucleic acid, winding into a helix
Helical symmetry
mostly used to distinguish different types of RNA viruses
Baltimore Classification/Scheme
is a proteinaceous infectious material
PRION
PRION’s structure is composed of
insoluble beta pleated sheet
PRION affects
NS such as fibrils and vacuole (spongy)
Normal cellular protein misfolded when a portion of its α-helical coil structure refolds to a β-sheet, producing a mutant protein
May be secreted in the urine
Transmissible spongiform encephalopathies (TSE)
Animal infection: Scrapie
sheep
Animal infection: Chronic wasting disease
Mule, deer, and elk
Animal infection: Transmissible mink encephalopathy
Mink
a family of progressive neurodegenerative disorders that affect both humans and animals
Human infection- Prion diseases
Types of prions
Sporadic
Genetic
Variant
Iatrogenic
What animal affects Bovine spongiform encephalopathy (BSE)
Cattle
Viral genomes contain information which:
ensures replication
packaging
alters structure
All are double stranded-DNA except
parvovirus
All are icosahedral DNA, except
Poxvirus(COMPLEX)
All are enveloped, Except
Papovavirus
Adenovirus
Parvovirus
All multiply in nucleus, Except
Poxvirus (cytoplasm)
Largest DNA virus
poxvirus
smallest DNA virus
Parvovirus