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CPR 2nd half > viral URT infections > Flashcards

viral URT infections Flashcards

1
Q

treat adenovirus

A

symptomatic

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2
Q

rhinovirus structure

A

nonenveloped, icosahedral capsule +ssRNA genome small size temperature sensitive

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3
Q

treatment for rhinovirus

A

symptomatic sanitation helps prevent spread

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3
Q

respiratory syncytial virus (RSV)

A

paramyovirus family

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3
Q

summary = rhinovirus, RSV, adenovirus, EBV site of replication for each

A

cyto - rhino, rsv nucleus - adeno, ebv

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4
Q

respigam vs palivizumab (synagis)

A

prevents RSV Synagis>x100>> respigam s- monoclonal ab (anti F reactive ab) r- polyclonal ab

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4
Q

adenovirus structure

A

ds linear DNA genome icosahedral capsid, largest nonenveloped virus replicates in nucleus

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4
Q

diagnosis for rhinovirus, rsv, adenovirus, ebv

A

rhino - symptoms rsv - antigen detection by ELISA/IFA, viral culture, PCR adeno - antigen detection by ELISA/IFA, viral culture, PCR ebv - heterophile Ab, atypical lymphocytes, Ab viz ELISA, PCR

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5
Q

what causes 1/3 of all adult common colds?

A

rhinovirus

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5
Q

what encodes its own dna dependent dna polymerase?`

A

ebv

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6
Q

what causes infectious mononucleosis

A

ebv

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7
Q

pathogenesis of RSV

A

entry as aerosol/fomite via nose/eye epithelia self limiting infection, 7-10 days causes runny nose, fever, rapid breathing, wheezing, coughing, lips turn blue

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8
Q

primary receptor for ebv infection

A

CD21 (CR2)

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10
Q

how is rhinovirus transmitted?

A

aerosol droplets and direct contact many cases coincide with sept to april school year

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11
Q

rhinovorus causes these inflammatory responses:

A

nasal discharge and congestion sneezing, sore throat edema, erythema aches, fatigue, loss of appetite

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12
Q

diagnose RSV

A

anitgens in nasal swab or aspirate use DFA or ELISA viral culture PCR

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12
Q

immunity for adenovirus

A

by 10, most have antibodies against common serotypes cell mediated CD8 CTL response controls infections

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13
Q

diagnosis adenovirus

A

antigen detected in aspirate/throat swab virus isolation serology - complement fixation test pcr

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13
Q

EBV structure

A

enveloped large genome linear dsDNA icosahedral capsid encodes its own dna dependent dna polymerase replicates inside nucleus?

14
Q

genes expressed in EBV latency

A

EBERs or EBNA1(type 1 burkitt lymphoma)

16
Q

what location does rhinovirus prefer and why?

A

grows and replicates better in NOSE at 88-90 degrees than at 98 in the lungs temperature sensitive

17
Q

adolesent infection leading to infectious mononucleosis that causes EBV

A

kissing disease

18
Q

rhinovirus encodes its own_______?

A

rna polymerase

20
Q

why do rsv infections repeat alot?

A

protective immunity is shortlived

20
Q

epstein barr virus (ebv)

A

a herpes virus infects epithelial cells and lymphocytes lays latent

22
Q

primary site for RSV replication?

A

nasopharyngeal epithelium

23
Q

diagnosis for infectious mononucleosis

A

1) atypical lymphocytes (downey cells = cd8 ctl) 2) agglutination test for heterophile Ab 3) EBV antibody ELISA 4) PCR

24
Q

clinical presentation for each: rhinovirus, rsv, adenovirus, ebv

A

rhino - cold like rsv - URT, croup, bronchiolitis adeno - pharyngitis, conjunctavitis, ARD, pneumonia ebv - infectious mono, exudative pharyngitis, cervial, lymphadenopathy

26
Q

respiratory syncytial virus structure

A

enveloped, helical capsule -ssRNA genome two envelope proteins = F (fusion) and G(attachment) forms syncytium

27
Q

transmission of adenovirus?

A

direct contact - fecal-oral, contaminated water, aerosol droplets epidemic in military facilites

28
Q

atypical lymphocytes indicates

A

EBV

29
Q

treatment for ebv

A

symptomatic self limiting and controlled by immune system

31
Q

adenovirus location and replication

A

infects mucoepithelial cells and persissts in lymphoid tissues/kidneys encodes its own DNA plymerase to copy the DNA replicates in nucleus

32
Q

respiratory syncytial virus encodes its own……?

A

rna dependent rna polymerase

33
Q

rhinovirus replication

A

+ssRNA VP4 binds receptor after entry viral mRNA binds DIRECTLY to ribosomes to make polyprotein polyprotein is cleaved by viral proteases to make VP0, VP1, and VP3 proteins viral rna dependent rna polymerase makes -ssRNA to make new +ssRNA genome and proteins self assemble and cytolysis releases new viruses

35
Q

what replicates in nucleus?

A

adenovirus and ebv

37
Q

what receptor does rhinovirus use to invade respiratory epithelial cells?

A

ICAM - 1

38
Q

symptoms of ebv/mononucleosis?

A

throat - sore, red (pharyngitis) tonsils - swollen, red, white patches lymph nodes - swollen

39
Q

treatment for RSV

A

no vaccine available ribavirin has limited efficacy oxygen treatment for infants passive immunotherapy - respigam or synagis (palivizumab)

40
Q

summary = rhinovirus, RSV, adenovirus, EBV genome, capsid, and envelope for each

A

rhino - +ssRNA, icosahedral, nonenveloped rsv - -ssRNA, helical, enveloped adeno - dsDNA, icosahedral, nonenveloped ebv - dsDNA, icosahedral, enveloped

41
Q

what gives immunity to rhinovirus?

A

mucosal IgA type 1 interferons(control viral spread, but induce pathogenecity) currently no vaccines due to >100 serotypes

42
Q

two outcomes of adenovirus

A

lytic in mucoepithelial cells latent in adenoid cells

43
Q

DNA virus?

A

adenovirus

44
Q

adenovirus 3,7 ? adenovirus 4, 7?

A

pharyngoconjunctival fever - crowded places, pools, camps acute respiratory disease - military

45
Q

how to diagnose rhinovirus

A

symptoms, virus culture, PCR nasal samples

CPR 2nd half (6 decks)

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