Viral STIs Flashcards
1
Q
What are the two major forms of HIV and where are they found?
A
HIV-1 Everwhere
HIV-2 West Africa
2
Q
What is the HIV receptor and co-receptor?
A
CD4 binds to gp120
CCR5 binds to gp41 - allows fusion of envelopes
3
Q
What are prognostic indicators of faster HIV disease progression?
A
Higher viral load and lower CD4+ T cell count
4
Q
What are the routes of sexual HIV transmission?
A
Greater in women and MSM Vaginal epithelium gets broken Endocervical cells (ectopy) Rectal simple columnar epithelium is easy damaged and has lymphocitic infiltrate Internal prepuse not keratinized
5
Q
When is HIV transmission more likely?
A
Acute phase and stage 3 - high viral loads
STI coinfection
6
Q
What are symptoms of acute HIV infection?
A
Flu like symptoms
Lymphadeopathy
7
Q
How do you diagnose HIV?
A
HIV ab ELISA
p24 ELISA
Western blot of all HIV proteins
8
Q
How do you prevent HIV?
A
Avoid unprotected sex Frequent testing Treating all STIs Treatment during pregnancy and elective cesarean Post-natal care (ARV) Treat high-risk populations with ARVs
