Viral Infections of the Skin 1a: Intro, HSV1, HSV2

Question 1

Give the term for a non-infectious inflammation of the skin

Answer 1

Dermatitis

Question 2

Give the term for an eruptive, infectious rash

Answer 2

Exanthem

Question 3

Give the term for a flat, discolored patch

Answer 3

Macule

Question 4

Give the term for a raised, discolored patch

Answer 4

Papule

Question 5

Give the term for a raised, fluid-filled blister

Answer 5

Vesicle

Question 6

Give the term indicating redness in the skin

Answer 6

Erythema

Question 7

Give the term for tiny, dark spots due to localized hemorrhage

Answer 7

Petechiae

Question 8

Give the term indicating itchiness in the skin

Answer 8

Pruritis

Question 9

Give the term for a vesicle filled with pus

Answer 9

Pustule

Question 10

Give the term for a pus-filled vesicle with a dimple in the center

Answer 10

Umbilical rash

Question 11

Put the following viruses in order from most to least common: Coxsackie, HPV, Measles, Rubella, Herpesviruses, Poxviruses

Answer 11

Herpesviruses, Coxsackie virus, HPV, poxviruses, measles, rubella

Question 12

Name the 6 groups of herpesviruses.

Answer 12

Herpes simplex (HHV1 and 2)
Varicella zoster (HHV3)
Epstein Barr (HHV4)
Cytomegalovirus (HHV5)
Roseola (HHV6 and 7)
KSHV (HHV8)

Question 13

Give the 4 stages that characterize herpesvirus infections.

Answer 13

Exposure/transmission - primary infection - latency - recurrence

Question 14

In what 2 cell types do herpesviruses hang out during latency?

Answer 14

Neurons and lymphocytes

Question 15

What is the major route of transmission of herpesviruses?

Answer 15

Secretions, especially saliva, to mucous membranes

Question 16

What is the most common herpesvirus stage to present with skin rash?

Answer 16

Primary infection

Question 17

Most individuals are infected by how many strains of herpesvirus? At what age do most people acquire a primary herpes infection?

Answer 17

3 strains; acquired in childhood

Question 18

During what stage of a herpesvirus infection are no symptoms are present but the virus can still be spread? What term describes this spread?

Answer 18

Latency; asymptomatic shedding

Question 19

What is the major difference in clinical presentation of HSV-1 vs HSV-2?

Answer 19

HSV-1 (oral) is above the waist, while HSV-2 (genital) is below the waist (but this differentiation is disappearing)

Question 20

What herpesvirus presents as cold sores / “canker sores” / fever blisters and can be triggered by fever, sunlight, or other stresses?

Answer 20

HSV-1

Question 21

What herpesvirus can cause T-cell mediated keratitis, corneal scarring, and blindness?

Answer 21

HSV-1 and HSV-2

Question 22

What disease is caused by direct skin contact of non-mucosal sites with HSV1 or 2, and results in chronic finger/hand/leg rashes similar to cold sores?

Answer 22

Herpetic Whitlow

Question 23

What virus presents as vesicular, pustular, or erythematous lesions of the penis, labia, anus, mouth, or eye accompanied by pain, itching, fever, malaise, and headache?

Answer 23

HSV-2 / genital herpes

Question 24

HSV-2 can spread to what major organ if not promptly treated with antivirals?

Answer 24

The brain

Question 25

During what stage of HSV-2 is congenital transmission most likely to occur?

Answer 25

Primary infection

Question 26

What is the difference in skin presentation between primary and recurrent HSV-2 infection?

Answer 26

The level of skin infection decreases in recurrent HSV-2