VIRAL INFECITONS

Question 1

First line treatment for herpes virus?

Answer 1

Local measures such as proper fluids, bed rest, proper diet, analgesics and antimicrobial mouthwashes such as chlorhexadine

Question 2

When and how to prescribe for herpes?

Answer 2

Treat infections in immunocompromised patients and severe in non ICP with aciclovir

1 tablet (200mg) , 5 times daily, for 5 days

Question 3

What viral patients would you refer?

Answer 3

Immunocompromised and severe infection

Bell’s palsy and infection

Question 4

How treat herpes labialis?

Answer 4

Aciclovir cream

5% cream in 2g tub

Apply to lesion every 4 hours, five times daily, for 5 days

Question 5

How treat shingles?

Answer 5

800mg aciclovir

1 tablet 5 times daily

For 7 days

Question 6

Method of action of aciclovir?

Answer 6

Its a prodrug so first it needs to convert to its active form
- aciclovir monophosphate

Then converted to aciclovir triphosphate

This competes and binds to the viral DNA
- when incorporated, it lacks chemical groups to carry on DNA synthesis, so the viral DNA is terminated