Viral inf. of the CNS Zoonotic Flashcards

1
Q

What is the definition of an arbovirus?

A

The spread of a disease from an INSECT to a human either directly or indirectly.

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2
Q

What viral CNS infections are most likely to cause Meningitis?

A

LCMV

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3
Q

What viral CNS infections are most likely to cause encephalitis?

A

Arboviruses
Rabies
LCMV

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4
Q

What viral infection can be found mostly in the “Dead end” host of Horses and humans?
What is the vector and amplifier/resevoir?

A

West Nile, transmitted by mosquitos and amplified by birds.

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5
Q

What percentage of people will develop a mild illness known as west nile fever?

A

20% of infected individuals with an incubation period of 3-14 days.

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6
Q

What is the cardinal symptom seen following west nile fever?

A

Sudden onset of febrile illness mostly seen in the elderly >50 years old!

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7
Q

What diseases should be considered in an adult >50 yrs old who presents with unexplained encephalitis/ meningitis in the summer/ fall?

A

WNV or other arboviral diseases should be considered in these cases.

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8
Q

What arbovirus is a MAJOR cause of encephalitis in the USA?

A

St. Louis Encephalitis Virus (SLE)

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9
Q

What is the vector and reservoir for St. Louis Encephalitis Virus?

What is the incubation period?

A

The Culex mosquito serves as the vector acquiring the virus from birds with horses serving as the resevoir.

Again, seen primarily during summer and early fall.

Incubation:5-15 days

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10
Q

What are the reservoirs for Japanese encephalitis Virus and where is it most prevalent?

A

The reservoirs are birds and livestock and the virus is most commonly found causing encephalitis in Asia.

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11
Q

Amongst the toga viruses, which two are most known to cause viral encephalitis in the US?

A

Eastern Equine Encephalitis (EEE) and Venezuelan Equine Encephalitis virus (VEE)

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12
Q

Where is Eastern Equine Encephalitis most commonly found in the US and during what seasons?

What is the incubation period?

A

EEE is most commonly found in the gulf coast and some areas in the midwest appearing most in the summer and fall months.

Incubation: 4-10 days

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13
Q

Where is Western Equine Enephalitis Virus most commonly found?

What season is Western Equine Encephalitis typically seen?

A

Typically found within the Western parts of the USA and Canada.

Typically seen in June or July within children moreso than adults.

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14
Q

Where is Venezuelan equine encephalitis virus most typically found and what is unique about it?

A

Typically found within South and Central America. This virus is unique because it will always cause symptoms typical of the flu.

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15
Q

Where is LACROSSE Encephalitis virus typically found?

A

Typically found in the Midwestern and Mid-Atlantic states mostly in children.

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16
Q

What is the vector for LACROSSE encephalitis?

A

Virus is maintained by chipmunks and tree squirrels.

It is then transported by mosquitos.

17
Q

How many people recieve post rabies exposure prophylaxis in the US annually?

A

15-40 thousand individuals.

18
Q

What is a classical sign of rabies infection?

A

Hydrophobia appears in 50% of all rabies cases.

19
Q

How does Rabies reach the CNS?

A

Rabies enters through wound or mucous membrane and incubates in the CNS where it will then rapidly disseminate to the peripheral nerves.

20
Q

What is the treatment plan for Rabies?

A

1 dose of immune globulin and 5 doses of vaccine administered over a 28-day period.

the first dose of immunoglobulin and vaccine are given immediately.

Following vaccine doses given on days 3, 7, 14, and 28.

21
Q

The presence of Negri bodies post morten represents what infection?

A

Negri bodies in animals post-mortem displays Rabies infection.

22
Q

How is Lymphocytic choriomeningitis virus contracted?

A

This virus is contracted by inhaling infectious aerosolized particles of rodent urine, feces, or saliva or ingesing contaminated food.

23
Q

What rodent specifcially is known to transfer Lymphocytic choriomeningitis?

A

The Mus musculus common house mouse.

24
Q

What is unique about Lymphocytic Choriomeningitis viral infections?

A

It causes a Biphasic febrile illness.
1st week of fever, malaise, anorexia, muscle aches.

Second phase: Meningitis/ encephalitis.

25
Q

What did Carlton Gajdusek discover?

A

This man demonstrated the transmission of human spongiform encephalopathy (Kuru)

26
Q

What did Stanley Prusiner identify?

A

This man identified that prions were small poteinaceous infectious particles.

27
Q

What two components make up a prion?

A

Prions completely lack genetic nucleotides but are composed of aggregates of protease and heat and chemically resistant hydrophobic glycoproteins known as Prion protein (PrP).

28
Q

What is the main difference between the natural PRPc and the infectious PRPSc prion proteins?

A

PrPc is mostly composed of alpha-helices.

PrPSc has a globular conformation with beta-plated sheets.

29
Q

How are prions typically replicated?

A

PrPc is changed to PrPSc from external binding. The cell will then create more PrPc and the cycle continues.

Neurons then ingest the PrPsc fibrils that form causing amyloid plaques to collect in lysosomes.

30
Q

What percentage of prion inheritence is thought to occur?

A

15-20% of all cases are thought to occur through inheritance of the mutated PrP gene.

The rest of the cases are thought to occur sporadically.