Viral Hepatitis Serology

Question 1

Acute HAV serology

Answer 1

anti-HAV IgM

Question 2

Previous HAV infection serology

Answer 2

anti-HAV IgG (with absence of anti-HAV IgM)

Question 3

• HBsAg
• Anti-HBs Ab
  + Anti-HBc IgM
• Anti-HBc IgG
• HBe Ag
  + HBV DNA

Answer 3

Acute HBV window period serology

Window period is time between HBsAg diseappearing and anti-HBs Ab appearing

Question 4

\+ HBsAg
- Anti-HBs Ab
\+ Anti-HBc IgM
- Anti-HBc IgG
\+ HBe Ag
\+ HBV DNA

Answer 4

Acute HBV infection

+HbsAg and +HBc IgM without anti-HBsAb or anti-HBc IgG indicate acute infection

HBeAG is present in acute infection, chronic exacerbation because virus is active

Question 5

- HBsAg
\+ Anti-HBs Ab
- Anti-HBc IgM
\+ Anti-HBc IgG
- HBe Ag
- HBV DNA

Answer 5

Prior HBV infection

*indicated by + HBs Ab with + HBc IgG because HBc IgG would be absent in immunization

Question 6

\+ HBsAg
- Anti-HBs Ab
- Anti-HBc IgM
\+ Anti-HBc IgG
- HBe Ag
\+/- HBV DNA

Answer 6

Chronic inactive HBV infection

+ HBsAG indicates infection, + Anti-HBc IgG without Anti-HBs Ab indicates long term infection without resolution

Anti-HBs Ab indicates immunization or resolution

Question 7

\+ HBsAg
- Anti-HBs Ab
\+ Anti-HBc IgM
\+ Anti-HBc IgG
\+ HBe Ag
\+ HBV DNA

Answer 7

Active flare of chronic HBV infection

+ HBsAG indicates infection, + Anti-HBc IgG and IgM indicates long term infection with acute flare

HBeAG is present in acute infection, chronic exacerbation because virus is active

Question 8

- HBsAg
\+ Anti-HBs Ab
- Anti-HBc IgM
- Anti-HBc IgG
- HBe Ag
- HBV DNA

Answer 8

Immunization against HBV

Only exposed to surface Ag by vaccine

Question 9

HDV serology

Answer 9

HDV RNA (PCR)
HDV Ag, IgG or IgM

*Requires HBV infection!