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GI 2 Exam 2 > HBV and HCV Pharm > Flashcards

HBV and HCV Pharm Flashcards

1
Q

***Treatment goal for chronic HBV infection vs HCV infection

A

HBV cannot be eradicated. Goals of tx are

  • Suppression of HBV DNA to undetectable levels
  • Reduction in serum aminotransferases

HCV goal is eradication

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2
Q

Entecavir indication and MOA

A

Chronic HBV treatment

NucleoSIDE analog that inhibits reverse transcriptase

Adults or Pediatric patients

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3
Q

Entecavir contraindications

A

None

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4
Q

Tenofovir Disproxil indication and MOA

A

Chronic HBV treatment

NucleoTIDE analog that inhibits reverse transcriptase

Adults or Pediatric patients

*nephrotoxicity

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5
Q

Adefovir indication and MOA

A

Chronic HBV treatment

NucleoTIDE analogue that inhibits reverse transcriptase

*nephrotoxicity

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6
Q

Lamivudine indication and MOA

A

Chronic HBV treatment

NucleoSIDE analog that inhibits reverse transcriptase

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7
Q

Telbivudine indication and MOA

A

Chronic HBV treatment in adults

NucleoSIDE analog that inhibits reverse transcriptase

Adult patients

*do not combine with PEG IFN-a-2a, risk of peripheral neuropathy

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8
Q

Telbivudine contraindications

A

do not combine with PEG IFN-a-2a

risk of peripheral neuropathy

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9
Q

PEG IFN-a-2a indication and MOA

A

Chronic HCV or HBV treatment

binds IFN-a receptors, activating JAK/STAT pathway which increases expression of genes involved in antiviral response

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10
Q

What two HBV drugs should not be given to patients with renal impairment?

A

Tenofovir

Adefovir

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11
Q

PEG IFN-a-2b indication and MOA

A

Chronic HCV treatment

binds IFN-a receptors, activating JAK/STAT pathway which increases expression of genes involved in antiviral response

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12
Q

PEG IFN-a contraindications

A

Hypersensitivity to drug
AIH
Decompensated liver dz
Babies

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13
Q

Elbasvir + Grazoprevir indication and MOA

A

Chronic HCV

NS5A inhibitor + NSC/4A protease inhibitor

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14
Q

Ledipasvir + Sofosbuvir indication and MOA

A

Chronic HCV

NS5A inhibitor + NS5B polymerase inhibitor

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15
Q

Velpatasvir + Sofosbuvir indication and MOA

A

Chronic HCV

NS5A inhibitor + NS5B polymerase inhibitor

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16
Q

Velpatasvir + Sofosbuvir contraindication

A

pregnancy and hemoglobinopathy (same as ribivirin)

Polyglycoprotein/CYP inducers

17
Q

Ribivirin (+ PEG IFN-a-2a) indication and MOA

A

Chronic HCV

Adults and pediatric (over 5)

Guanosine nucleoSIDE analog that inhibits reverse transcriptase
(ribivirin)

18
Q

Ribivirin contraindication

A

Pregnant women

Hemoglobinopathies

19
Q

Boceprevir (+ Ribivirin + PEG IFN-a) indication and MOA

A

Chronic HCV in pt who failed Rib+IFN alone

NS3/4A protease inhibitor

20
Q

Prefix for NS5A inhibitors for HCV infection

A

-asvir

Velpastasvir
Elbasvir
Ledipasvir

21
Q

Prefix for NS3/4A protease inhibitors for HCV infection

A

-previr

Boceprevir
Grazoprevir

22
Q

Prefix for NS5B polymerase inhibitors for HCV infection

A

-buvir

Sofosbuvir

23
Q

***Pharmacokinetics of PEGylated IFN-a-2a/2b vs IFN-a-2b

A

PEGylated IFN-a-2a/2b allows the drug to stay in the body longer before being broken down and excreted, decreasing the dose required for effectiveness

24
Q

***PEG IFN-a black box warning

A

Risk for neuropsychiatric, autoimmune, ischemic, and infectious disorders

less serious but may cause flu like symptoms as a side effect

25
Q

Combination therapies for HCV

A

VS - Velpatasvir + Sofosbuvir
LS - Ledipasvir + Sofosbuvir
EG - Elbasvir + Grazoprevir

  • asvir = NS5A inhibitor
  • buvir = NS5B polymerase inhibitor
  • previr = NS3/4A protease inhibitor
26
Q

-asvir (Velpastasvir, Elbasvir, Ledipasvir) MOA

A

NS5A inhibitors

27
Q

-buvir (Sofosbuvir) MOA

A

NS5B polymerase inhibitor

28
Q

-previr (Boceprevir, Grazoprevir) MOA

A

NS3/4A protease inhibitor

GI 2 Exam 2 (7 decks)

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