VIRAL HEPATITIS Flashcards
Viruses causing HEPATITIS
- HAV
- HBV
- HCV
- HDV
- HEV
Family of Viruses
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Hepatitis A = Picornaviridae Family.
Hepatitis B = Hepadnaviridae Family.
Hepatitisc = Flavivirus.
Hepatitis D = Rna Incomplete Virus.
Hepatitis E = Calcivirus
Causes of Acute HEPATITIS
🧠⚡Acute ⚡
- HEPATITIS A
- HEPATITIS E
Viral Causes of Chronic HEPATITIS
🧠⚡Chronic⚡
🧠⚡+1 & -1 ⚡
HEPATITIS B
HEPATITIS C
HEPATITIS D
- ICOSAHEDRAL SYMMETRY
➕ - DO NOT HAVE ENVELOP
➕ - CAN CAUSE ACUTE LIVER FAILURE
➕ - ROUTE: FECO-ORAL Route
HEPATITIS A & E
Common Features
SPHERICAL SYMMETRY
➕
ENVELOPED
HEPATITIS B, C & D
Common Features
⚡⚡ MOST COMMON CAUSE of ALF in INDIA
⚡⚡ MOST COMMON CAUSE of ALF in WESTERN Countries
⚡⚡ MOST COMMON CAUSE of ALF in INDIA
🎯 HEPATITIS A & E
⚡⚡ MOST COMMON CAUSE of ALF in WESTERN Countries
🎯 PARACETAMOL Poisoning
HEPATITIS A
🧠⚡A ⚡
Asymptomatic
Acute
Alone (NO CARRIERS)
⚡⚡ MOST COMMON CAUSE of ACUTE RELAPSING VIRAL HEPATITIS
HEPATITIS A
All viral Hepatitis have ssRNA, except
HEPATITIS B (dsDNA)
Incubation periods of HEPATITIS Virus
HEPATITIS A: 4 weeks (30 days)
HEPATITIS E: 40 days
Extra-Hepatic Manifestations of HAV
🧠⚡A⁴PRIL ⚡
- Arthritis
- Adult onset Still’s syndrome
- Aplastic Anemia
- ATN
- Polymyositis
- Rhabdomyolysis
- Interstitial Nephritis
Serology of HEPATITIS A
Anti-HAV IgM coverts to IgA after
12 weeks
💊💉 MANAGEMENT of HEPATITIS A
- Hydration
- Glucose replenishment: 3 points of 10% DEXTROSE
Hepatitis A Vaccine
HAV-RIX Vaccine
Adult: 1 ml IM DELTOID
2DOSES (0, 6-12months)
Children: 0.5 ml IM
PRE-EXPOSURE Prophylaxis of HEPATITIS A
> 2 weeks PRIOR to Travel
POST-EXPOSURE Prophylaxis of HEPATITIS A
Within 2 weeks of Exposure
➕
HAV Ig
⚡⚡ MOST COMMON GENOTYPE OF HEPATITIS A in INDIA
⚡⚡ MOST COMMON GENOTYPE OF HEPATITIS E in INDIA
Both GENOTYPE 1
Difference BETWEEN HAV & HEV
💊💉 MANAGEMENT of ACUTE LIVER FAILURE with HEV
Ribaverin ± PEG-IFN-Alpha
SEROLOGY of HEPATITIS E
Anti-HEV IgM: ACUTE INFECTION
Anti-HEV IgG: Remote Infection
