Viral Gastroenteritis

Question 1

Viral gastroenteritis in children

Answer 1

rotavirus

Question 2

Viral gastroenteritis in adults

Answer 2

novavirus

Question 3

Sx of gastroenteritis

Answer 3

watery diarrhea w/o WBC or blood
emesis
“two bucket” infection

Question 4

Pathophys of viral gastroenteritis

Answer 4

infection of only GI epithelium
lysis of cells
secretory diarrhea
irriation –> emesis

Question 5

Dx of most viral gastroenteritis, if needed

Answer 5

RT-PCR for rota and norovirus

Question 6

Which virus that causes gastroenteritis has a toxin?

Answer 6

rotavirus

Question 7

NSP4

Answer 7

toxin in rotavirus
forms pores
leaks out fluid and electrolytes –> secretory diarrhea and electrolyte imbalances

Question 8

Vaccines for the general public are for this virus

Answer 8

rotavirus

Question 9

Rotateq

Answer 9

hijacked cow virus

attenuated infection provides immunity

Question 10

Rotarix

Answer 10

attenuated human virus

Question 11

Rotavirus capsule

Answer 11

double layer capsid
activated by digestive enzymes
provides protection from environment

Question 12

Function of double-layerd rotavirus capsule

Answer 12

protect from environment
activated by digestive enzymes
needle comes out to poke hole to get into next cell

Question 13

Enterovirus infections usually occur where in the GI tract

Answer 13

upper 2/3 of small bowel

Question 14

Adaptive immunity to norovirus

Answer 14

not good, short lived

virus mutates a lot

Question 15

RNA virus
icosahedral nucleocapsid
non-enveloped
dsRNA, segmented, class III
reoviridae

Answer 15

rotavirus

Question 16

RNA virus
icosahedral nucleocapsid
non-enveloped
ssRNA (+), class IV
calciviridae
calcivirus

Answer 16

norovirus/Norwalk virus

Question 17

DNA virus
icosohedral
non-enveloped
dsDNA class I
adenoviridae

Answer 17

adenovirus