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GI--Wk 4 > Antiemetics and IBD Tx > Flashcards

Antiemetics and IBD Tx Flashcards

1
Q 
-setrons
(dolasetron, granisetron, ondansetron, palonosetron)
MOA
TU
Tox
A

-setrons
MOA: 5-HT3 antagonists in central vomiting center and periphery
TU: acute phase chemo rxn, post-op and -radiation
Tox: constipation, dizziness, headache, subclinical QT elongation

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2
Q

Scopolamine
MOA
PK

A

scopolamine
MOA: mAChR antagonist, dopamine antagonist (esp in cerebellum)
PK: total CNS distribution, transdermal patch

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3
Q

Dimenhydrinate, diphenhydramine, meclizine
MOA
Tox

A

H1 antagonists
MOA: sedation, some mAChR antagonist
Tox: anti-mAChR, Abx interaction, not for pregnancy

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4
Q

Droperidol, metoclopramide, procholorperazine, promethazine, thiethylperazine
MOA

A

MOA: D2 antagonists in chemo-trigger zone, anti-muscarinic

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5
Q

Dronabinol
MOA
TU
Tox

A

dronabinol
MOA: central canibinoid receptors (sedation)
TU: chemo, co-Tx w/ phenothiazines
Tox: euphoria, sedation, hallucinations, dry mouth, increased appetite

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6
Q

Nabilone
MOA
TU
Tox

A

nabilone
MOA: central canibinoid receptors (sedation)
TU: chemo, co-Tx w/ phenothiazines
Tox: euphoria, sedation, hallucinations, dry mouth, increased appetite

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7
Q

Dexamethasone, methylprednisalone

MOA

A

corticosteroids

MOA: unknown in anti-emesis

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8
Q

Balsalazide, mesalamine, solsalazine, sulfasalazine
MOA
TU
Tox

A

Balsalazide, mesalamine, solsalazine, sulfasalazine
MOA: gut bacteria release R group, release ASA only in gut. only active in intestines after activation (not stomach)
TU: ulcerative colitis 1st line, not Crohn’s–high high []
Tox: sulfasalazine–hypersensitivity, BM suppression, folate uptake inhibition

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9
Q

Budesonide
MOA
TU

A

budesonide
MOA: corticosteroid
TU: Crohn’s, extensive 1st pass metabolism

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10
Q 
Infliximab
MOA
PK
TU
Tox
A

infliximab
MOA: TNF-α antibody, helps in dysregulation of Th1 cells and activates complement
PK: 1/3 develop Ab to infliximab –> refractory
TU: Crohn’s
Tox: infections, TB reactivation, increased lymphoma risk, hepatotox

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GI--Wk 4 (11 decks)

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