Viral Encephalitis Flashcards
Most common cause of viral encephalitis……, …..in primary infection of infants,……in reactivation following immunosppression of adults
HSV
2
1
……causes encephalitis particularly in immunosuppressed AIDS patients
CMV
Viruses that reach brain via axons are…..
HSV-1
Rabies
Describe Reye syndrome etiology
Influenza B, VZV & adenovirus have been implicated in conjunction with salicylates
Describe progression of HIV encephalitis
Virus enter brain within infected monocytes which fuse with resident microglia, resulting in activation & release of cytokines with 2ry brain injury. Its glycoproteins interfere with synaptic activity. HIV infects astrocytes leading to dementia
HSV infection is localized to……
Temporal & frontal lobes
Acyclovir is given in……, while……is given in CMV
HSV-1&2/Gancyclovir
Reservoir of WNV
Wild birds
Most efficient lab diagnosis for WNV
WNV specific IgM in CSF
Neurons infected with rabies contain…..
Negri bodies
Clinical forms of rabies are…….
Furious & paralytic
GR: Occurrence of hydrophobia with furious rabies
Because of painful spasm of pharyngeal muscles
Detail rabies PEP
- If person hasn’t recieved rabies vaccine since 5 yrs or incomplete, RIG & vaccine are recommended, discontinue if animal proven non-rabid, although no human-tohuman non-transplant tranmission is docmented, on exposure to fluids of patients infected PEP is recommended. HRIG should be infiltrated into and around wound and rest is given in gluteals IM. Vaccine is 1-ml four douses IM at 0,3,7,14
- Completed schedule of rabies in last 5 years, two booster doses
……is the standard for rabies vaccination
Human diploid cell vaccine
Pre-exposure prophylaxis of rabies involves
Three doses ar 0,7,27 or 28
