Video 5 Plasma Membrane Flashcards
Which are the receptors of the plasma membrane?
Tyrosine kinase receptors and G protein-coupled receptors, but Steroid receptors are in cytoplasm.
What is the first step in signaling cascade of the Tyrosine Kinase receptors?
Autophosphorylation.
Which is the most important protein in the receptor-mediated endocytosis?
Clathrin.
Which is the enzyme to convert the membrane phospholipids to arachidonic acid? And what drug inhibit this enzyme?
Phospholipase A2, corticosteroids.
Which are the effects of the leukotrienes?
Neutrophil chemotaxis and high bronchial tone.
Which are the effects of the prostacyclin 2?
Decrease platelet aggregation, vascular tone, bronchial tone and uterine tone.
Which are the effects of the prostaglandins ?
Increase uterine tone (PGF2 and PGE2), decrease vascular tone (PGE1), decrease bronchial tone and increase gastric mucus production.
Which are the effects of the Thromboxane?
Increase platelet aggregation,navicular tone and bronchial tone.
Which arachidonic acid product cause increased bronchial tone?
Leukotrienes and Thromboxane.
Which arachidonic acid product cause decreased bronchial tone?
Prostaglandins and prostacyclins
Which arachidonic acid product cause increased platelet aggregation?
Thromboxane
Which arachidonic acid product cause decreased platelet aggregation ?
Prostacyclin
Which arachidonic acid product cause increased uterine tone?
Prostaglandins (PGE2 and PGF2 alpha)
Which arachidonic acid product cause decreased uterine tone?
Prostacyclin
Which arachidonic acid product cause increased vascular tone?
Thromboxane
Which arachidonic acid product cause decreased vascular tone?
Prostaglandins, prostacyclin
What are the two most abundant substances in plasma membranes?
Proteins and phospholipids
Which enzyme is inhibit by corticosteroids?
Inhibit Phospholipase A2
Which enzyme is inhibit by Zileuton?
Inhibits lipoxygenase.
Which enzyme is inhibit by Zafirlukast and montelukast?
Inhibit leukotriene receptors
Which enzyme is inhibit by NSAIDs, acetaminophen, COX-2 inhibitors, aspirin?
Inhibit cyclooxygenase
What cell membrane lipid is converted to arachidonic acid by Phospholipase A2?
Phosphatidylinositol
Which are the components of the plasma membrane?
Phospholipid bilayer, proteins, glycoproteins, glycolipids, sphingolipids, cholesterol.
