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DIT Foundations > Video 4 Cytoplasm & Cytoskeleton > Flashcards

Video 4 Cytoplasm & Cytoskeleton Flashcards

1
Q

What is the function of the Microfilaments?

A

Muscle contraction and cellular motility. Example: Actin.

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2
Q

What is the function of the intermediate filaments?

A

Maintain cell structure.

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3
Q

What is the function of the Microtubules ?

A

Movement and cell division

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4
Q

Which are the immnunohistochemical stains of the intermediate filaments?

A

Vimentin, Desmin, Cytokeratin, glial fibrillary acid proteins (GFAP), Neurofilaments and Nuclear lamins.

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5
Q

Where can find vimentin?

A

Connective tissue (fibroblasts, leukocytes, endothelium).

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6
Q

Where can find Desmin?

A

Muscle cells (smooth, skeletal, heart).

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7
Q

Where can find Cytokeratin ?

A

Epithelial cells (keratin in desmosomes and hemidesmosomes.

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8
Q

Where can find GFAP?

A

Astrocytes, Schwann cells, other neuroglia.

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9
Q

Where can find peripherin ?

A

Neurons

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10
Q

Where can find Neurofilaments ?

A

L, M, H molecular weight, Axons within neuron.

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11
Q

Where can find nuclear lamins?

A

There are A, B and C in the nuclear envelope and DNA within.

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12
Q

Which are the nuclear lamin mutations?

A

Progeria and muscular dystrophy.

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13
Q

Which cancers are involved to Vimentin?

A

Sarcomas and some carcinomas.

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14
Q

Which cancer is involved to Desmin?

A

Myosarcomas; Rabdomyosarcoma and Leiomyosarcoma.

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15
Q

Which cancer is involved to Cytokeratin ?

A

Carcinomas (skin carcinomas)

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16
Q

Which cancers are involved to GFAP?

A

Astrocytoma, Glioblastoma.

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17
Q

Which cancers are involved to Neurofilaments?

A

Neuroblastoma and primitive neuroectodemal tumor.

18
Q

Which are the structures that composed the Microtubules?

A

Heterodimers alpha and Beta-Tubulin.

19
Q

Microtubules are incorporated into…

A

Flagella, Cilia and Mitotic spindles.

20
Q

What drugs act on Microtubules?

A

Mebendazol(antihelmintic), Griseofulvin(antifungal), Colchicine(antigout), Vincristine/Vinblastine (anticancer) and paclitaxel and docetaxel (anticancer).

“Microtubules Get Constructed Very Poorly”

21
Q

What does the function of the Molecular motor protein do?

A

Transport cellular cargo toward opposite ends of Microtubule tracks.

22
Q

Which are the 2 molecular motor proteins?

A

Dyne in and proteins.

23
Q

Which is the molecular motor protein that go retrograde to Microtubule (+ > -)?

A

Dynein

24
Q

Which is the molecular motor protein that go anterograde to Microtubule (- > +)?

A

Kinesin.

25
Q

Which are the 3 types of filaments?

A

1) Microfilaments.
2) Intermediate filaments.
3) Microtubules.

26
Q

How is the arrangement of the cilia structure?

A

9 + 2, Axonemal Dynein.

27
Q

Which is the type of junction of the cilia structure?

A

Gap Junction.

28
Q

Where can find Cilia?

A

Respiratory tract (trachea and bronchioles), paranasal sinuses and Fallopian tubes.

29
Q

What is the Kartagener syndrome?

A

AKC First ciliary dyskinesia, it is a immotile cilia due to a Dynein arm defect.

30
Q

What are the clinical manifestation of the Kartagener Syndrome?

A

Infertility (immotile sperm and dysfunctional Fallopian tube cilia), high risk of ectopic pregnancy.
Can cause bronchiectasis, recurrent sinusitis, and situs inversus.

31
Q

What inclusion is caused by Cytomegalovirus?

A

Owl’s eye inclusions

32
Q

What inclusion is caused by Rabies virus?

A

Negri bodies.

33
Q

What inclusion is caused by Herpes virus?

A

Cow dry bodies.

34
Q

What inclusion is found it in Alzheimer disease?

A

Neurofibrillary tangles.

35
Q

What inclusion is found it in Parkinson disease?

A

Lewy bodies

36
Q

Which are the lysosomal storage disorders?

A

Gaucherie disease, Niemann-pick disease and Tay-Sachs disease.

37
Q

Which are the mucopolysaccharidoses?

A

Hurler syndrome and Hunter syndrome.

38
Q

What drugs act on Microtubules?

A

1) Anticancer: Vincristine/Vinblastine, Paclitaxel/Docetaxel.
2) Anti-fungal: Griseofulvin.
3) Antihelmintic: Benzimidazole(mebendazole).
4) Antigout: Colchicine.

39
Q

What intermediate filaments are found in the following tissue types and cellular structures? 1-connective tissue, 2-Muscle tissue, 3-epithelial tissue and 4-Axons

A

1)Vimentin, 2)Desmin 3)Cytokeratin and 4)Neurofilaments.

40
Q

What are the defects seen in Kartagener syndrome?

A

Bronchiectasis, chronic sinusitis, situs inversus and infertility.

DIT Foundations (7 decks)

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