Vibrio cholerae Flashcards
1
Q
shape
A
gram (-) curved rods
2
Q
most common source of vibrio cholerae
A
fecally contaminated water
3
Q
cholera
A
secretory diarrhea (non-invasive)
4
Q
cholera toxin
A
A-B toxin
* A subunit locks a stimulatory regulatory G protein in the “actie” mode, turning on adenylate cyclase
* Adenylate cyclase causes the conversion of ATP to cAMP
* cAMP acitvates activates ion transport channels in the membrane causing Cl- and other electrolytes to pour of hte cell
* water follows electrolytes out of the cell by osmosis
5
Q
signs and symptoms
A
copious amounts of watery stool caled “rice water” stool
6
Q
cholera in children
A
dehydration –> lethargic, suken eyes, flaccid skin –> hypovolemic shock –> death
