H. pylori Flashcards
1
Q
causes
A
peptic ulcers
2
Q
signs and symptoms
A
epigastric pain
heart burn
nausea associated with eating
3
Q
shape
A
gram (-) curved rods or spiral shpaed
4
Q
cofactor in
A
stomach cancer
5
Q
reservoir
A
humans
6
Q
transmission
A
person-to-person saliva or fecal-oral
7
Q
produces
A
urease
8
Q
urease
A
breaks urea down into ammonia (increases the pH of the stomach)
9
Q
pathogenesis
A
- bacteria penetrate and multiply in mucus later
- bacteria attach but do not invade epithelium
- bacterial toxins ad the inflammatory response damages mucus-secreting cells
- acid juices damage to the exposed tissue, causing a peptic ulcer
10
Q
diagnosis
A
gastric mucosal biopsy and urease test
* biospy sample is placed in media containing urea
* If H. pylori is present, its urease will hydrolyze the urea, causing a pH shift and color change
11
Q
treatment
A
antacids and antibiotics
