VI - Drugs Used in the Treatment of Angina Pectoris

Question 1

Amyl Nitrites are Ultrashort-acting nitrate. MOA: Releases nitric oxide (NO), increases cGMP (cyclic guanosine monophosphate) and relaxes smooth muscle, especially vascular.

Answer 1

Uses: Cyanide poisoning SE: Reflex tachycardia, Orthostatic hypotension, Headache, Methemoglobinemia

Question 2

Which portion of the electron transport chain is affected by cyanide?

Answer 2

Complex IV (cytochrome oxidase) of the Electron Transport Chain.

Question 3

What is the antidote for cyanide poisoning?

Answer 3

Inhaled Amyl nitrite + IV sodium nitrite + IV sodium thiosulfate

Question 4

A disease characterized by alternating development of tolerance and loss of tolerance caused by occupational exposure to nitrates.

Answer 4

Monday disease.

Question 5

Nitroglycerin is a Short-acting nitrate. MOA: Releases nitric oxide (NO), increases cGMP and relaxes smooth muscle, especially vascular.

Answer 5

Uses: Angina, Acute coronary syndrome SE: Reflex tachycardia, Orthostatic hypotension, Headache, Tolerance (Transdermal)

Question 6

Why do patients taking nitrates usually experience throbbing headaches?

Answer 6

Due to minengeal artery vasodilation

Question 7

Nifedipine is a Dihydropyridine Calcium channel blocker. MOA: Non-selective block voltage-gated L-type calcium channels. More Vascular depressant.

Answer 7

Uses: Angina, Hypertension. SE: Constipation, Pre-tibial edema, Nausea, Flushing, Dizziness.

Question 8

Verapamil is a Non-dihydropyridine Calcium channel blocker. MOA: Non-selective block voltage-gated L-type calcium channels. Cardiac depressant

Answer 8

Uses: Angina, Hypertension, Supraventicular tachycardia, Migraine. SE: Pretibial edema, Gingival hyperplasia, Heart failure, AV block, Sinus node depression

Question 9

Diltiazem is a Non-dihydropyridine calcium channel blocker. MOA: Block voltage-gated L-type calcium channels..

Answer 9

Uses: Angina, Hypertension, Supraventricular tachycardia, Vasospasm, Reynaud’s phenomenon. SE: Constipation, Pre-tibial edema, Flushing, Dizziness, Sinus node depression

Question 10

Why is calcium-dependent neurotransmission or hormone release not affected by Calcium Channel Blockers?

Answer 10

Calcium channel blockers block L-type calcium channels, other functions us N-,P- and R-types.

Question 11

What drugs can cause gingival hyperplasia?

Answer 11

Nifedipine, Cyclosporine, Phenytoin, Verapamil (NapaCa-Pangit ng giginiVa mo.

Question 12

Propanolol is a Beta-receptor blocker and adrenergic antagonist. MOA: Blocks sympathetic effects on heart and blood pressure; Reduces renin release.

Answer 12

Uses: Angina prophylaxis, Hypertension, Arrhythmias, Migraine,. SE: Excessive Beta blockade: Bronchospasm, AV block, Heart failure, CNS sedation, Masks hypoglycemia in diabetics, Erectile dysfunction.