Vertebrates 1 - History Flashcards
SPCA
Founded in 1866, in USA
AWA
Animal welfare act, 1966, in USA
Trends in animal use
Huge increase since WWII to 1970 (increased funding), then decreased to present (ethics, accurate results?)
3 R’s of Humane Animal Experimentation (Russel and Birch)
Replacement (cell culture/inverts over rats); Reduction (less animals with loss of data, 1000 or 100 - save money!); Refinement (change techniques, less pain/stress)
Animal research in Canada
No legislation direct for animals (fed. or prov.); some committees for ethics and researchers
Where are most animals used in Canada?
Mostly in research, very few (relatively) in testing and teaching
Levels of Anatomy and physiology
Molecular; organelle; cellular; tissue (most tissues are the same); organ; organ system; organism
Philosophers
Aristotle, Hippocrates, Plato; wrote about animals, how body works; just observed, no experiments
Herophilus
300BC. Father of anatomy; autopsies to compare humans and animals
Galen
around 1AD; Physician and philosopher, experimental physiology; live dissection
1500-1600
Age of autopsy. Da Vinci paintings, Vesalius Textbook
1600-1700
Descartes, Hooke; microscope, cell,
1700-1800
van Leeuwenhoekl, Galvani; comparative anatomy, electricity in physiology
1800-1900
Schwann, Schleider (cell theory); Darwin; Broca; Cajal (pathways in brains); Rontgen (Xrays)
1900-pres
Pavlov (Behaviour), Berger (human brain, ECG), Young (comparative anatomy), Hodgkin and Huxley (vision/brain), Hubel and Weisel, Axel and Buck (olfactory)